Abstract
Previous studies have shown that the functional development of auditory
system is substantially influenced by the structure of environmental
acoustic inputs in early life. In our present study, we investigated
the effects of early auditory enrichment with music on rat auditory
discrimination learning. We found that early auditory enrichment
with music from postnatal day (PND) 14 enhanced learning ability
in auditory signal-detection task and in sound duration-discrimination
task. In parallel, a significant increase was noted in NMDA receptor
subunit NR2B protein expression in the auditory cortex. Furthermore,
we found that auditory enrichment with music starting from PND 28
or 56 did not influence NR2B expression in the auditory cortex. No
difference was found in the NR2B expression in the inferior colliculus
(IC) between music-exposed and normal rats, regardless of when the
auditory enrichment with music was initiated. Our findings suggest
that early auditory enrichment with music influences NMDA-mediated
neural plasticity, which results in enhanced auditory discrimination
learning.
- acoustic
- colliculi,inferior
- colliculi:
- cortex,auditory
- cortex:
- learning,discrimination
- learning:
- metabolism,auditory
- metabolism,inferior
- metabolism,newborn,rats,receptors,sprague-dawley,western,music,neuro,perception
- methods,analysis
- of
- perception,auditory
- perception:
- physiology,auditory
- physiology,blotting,discrimination
- physiology,inferior
- physiology,male,music,n-methyl-d-aspartate,n-methyl-d-aspartate:
- stimulation,acoustic
- stimulation:
- variance,animals,auditory
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