%0 Journal Article %1 Lohse2010 %A Lohse, M. J. %D 2010 %J Curr Opin Pharmacol %K *Signal Binding G-Protein-Coupled/chemistry/*metabolism Humans Ligands Multimerization Protein Transduction Transport Receptor %N 1 %P 53-8 %T Dimerization in GPCR mobility and signaling %U http://www.ncbi.nlm.nih.gov/pubmed/19910252 %V 10 %X Many types of cell surface as well as intracellular DNA-binding receptors exist and function as dimers; formation of homodimers or heterodimers appears to not only provide molecular mechanisms for agonist-induced activation but also increase specificity of ligand recognition and versatility of downstream signaling. G-protein-coupled receptors (GPCRs) were long thought to be an exception, but in recent years a lot of evidence has accumulated that GPCRs also can form dimers, even though it is far from certain when and where they actually do so under physiological conditions. Dimerization of GPCRs does not generally seem to be required for ligand recognition or signaling. However, dimerization may serve to affect receptor mobility at the cell surface and in intracellular trafficking, and may be involved in and affect their signaling functions.

@article{Lohse2010, abstract = {Many types of cell surface as well as intracellular DNA-binding receptors exist and function as dimers; formation of homodimers or heterodimers appears to not only provide molecular mechanisms for agonist-induced activation but also increase specificity of ligand recognition and versatility of downstream signaling. G-protein-coupled receptors (GPCRs) were long thought to be an exception, but in recent years a lot of evidence has accumulated that GPCRs also can form dimers, even though it is far from certain when and where they actually do so under physiological conditions. Dimerization of GPCRs does not generally seem to be required for ligand recognition or signaling. However, dimerization may serve to affect receptor mobility at the cell surface and in intracellular trafficking, and may be involved in and affect their signaling functions.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Lohse, M. J.}, biburl = {https://www.bibsonomy.org/bibtex/283751ab92c7de781ceae991df34f105b/pharmawuerz}, endnotereftype = {Journal Article}, groups = {private}, interhash = {74b4c93afb48034636629ebd9af8ad88}, intrahash = {83751ab92c7de781ceae991df34f105b}, issn = {1471-4973 (Electronic) 1471-4892 (Linking)}, journal = {Curr Opin Pharmacol}, keywords = {*Signal Binding G-Protein-Coupled/chemistry/*metabolism Humans Ligands Multimerization Protein Transduction Transport Receptor}, month = Feb, note = {Lohse, Martin J Research Support, Non-U.S. Gov't Review England Current opinion in pharmacology Curr Opin Pharmacol. 2010 Feb;10(1):53-8. Epub 2009 Nov 10.}, number = 1, pages = {53-8}, shorttitle = {Dimerization in GPCR mobility and signaling}, timestamp = {2010-12-14T18:20:05.000+0100}, title = {Dimerization in GPCR mobility and signaling}, url = {http://www.ncbi.nlm.nih.gov/pubmed/19910252}, volume = 10, year = 2010 }