%0 Journal Article %1 Wang2011Discovering %A Wang, Zhihui %A Bordas, Veronika %A Deisboeck, Thomas S. %D 2011 %J Drug development research %K cancer drug-targets multi-scale-modelling %N 1 %P 45--52 %R 10.1002/ddr.20401 %T Discovering Molecular Targets in Cancer with Multiscale Modeling. %U http://dx.doi.org/10.1002/ddr.20401 %V 72 %X Multiscale modeling is increasingly being recognized as a promising research area in computational cancer systems biology. Here, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross-scale analytical technique can be useful in identifying high-value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step towards systems medicine.

@article{Wang2011Discovering, abstract = { Multiscale modeling is increasingly being recognized as a promising research area in computational cancer systems biology. Here, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross-scale analytical technique can be useful in identifying high-value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step towards systems medicine. }, added-at = {2018-12-02T16:09:07.000+0100}, author = {Wang, Zhihui and Bordas, Veronika and Deisboeck, Thomas S.}, biburl = {https://www.bibsonomy.org/bibtex/2961ec9ecb8184ea445dd05dc4a264ec6/karthikraman}, citeulike-article-id = {9318866}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/ddr.20401}, citeulike-linkout-1 = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092304/}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/21572568}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=21572568}, day = 1, doi = {10.1002/ddr.20401}, interhash = {795f03cbe9c37fdc47c4f6736091063f}, intrahash = {961ec9ecb8184ea445dd05dc4a264ec6}, issn = {0272-4391}, journal = {Drug development research}, keywords = {cancer drug-targets multi-scale-modelling}, month = feb, number = 1, pages = {45--52}, pmcid = {PMC3092304}, pmid = {21572568}, posted-at = {2011-05-20 13:03:19}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Discovering Molecular Targets in Cancer with Multiscale Modeling.}, url = {http://dx.doi.org/10.1002/ddr.20401}, volume = 72, year = 2011 }