%0 Journal Article %1 Wong2004a %A Wong, Alice M K %A Chen, Chia-Ling %A Chen, Carl P C %A Chou, Shih-Wei %A Chung, Chia-Ying %A Chen, Max J L %D 2004 %J Am J Phys Med Rehabil %K Botulinum Toxin Type A; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Lower Extremity; Male; Muscle Spasticity; Neuromuscular Agents; Blockade; Phenol; Treatment Outcome %N 4 %P 284--291 %T Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy. %V 83 %X OBJECTIVE: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.

@article{Wong2004a, abstract = {OBJECTIVE: To compare the treatment effectiveness of botulinum toxin type A (BTX-A) and phenol blocks in managing lower limb spasticity and gait dysfunction in children with cerebral palsy. DESIGN: This is a case-controlled study that took place in a tertiary center's gait laboratory. A total of 27 ambulatory children with cerebral palsy spastic diplegia, aged from 3 to 7 yrs, and 20 normal children were recruited into this study. Sixteen children with cerebral palsy received BTX-A injections, and 11 received phenol motor point blocks. Gait analyses were assessed by a portable computer-assisted system (Computer DynoGraphy, Infotronic, The Netherlands). Both the BTX-A and phenol groups received gait analysis at 1 wk before and 2 mos after injection treatments. RESULTS: Significant improvements in gait variables of velocity and cadence were noted in children with cerebral palsy after BTX-A injections as compared with the phenol block group. Gaitline and cyclogram patterns also improved significantly in the BTX-A group. The adverse clinical effects of BTX-A injections were less severe as compared with phenol injections. CONCLUSIONS: BTX-A injections demonstrated superior treatment effects in improving gait variables and patterns in children with spastic diplegia as compared with phenol blocks. BTX-A injections also revealed fewer clinical side effects and were well tolerated by children with cerebral palsies.}, added-at = {2014-07-19T21:56:27.000+0200}, author = {Wong, Alice M K and Chen, Chia-Ling and Chen, Carl P C and Chou, Shih-Wei and Chung, Chia-Ying and Chen, Max J L}, biburl = {https://www.bibsonomy.org/bibtex/2758857c61cd27475f203e1aa560999ca/ar0berts}, groups = {public}, interhash = {7d52067cc7a57f01f28f27905ec0af55}, intrahash = {758857c61cd27475f203e1aa560999ca}, journal = {Am J Phys Med Rehabil}, keywords = {Botulinum Toxin Type A; Case-Control Studies; Cerebral Palsy; Child; Child, Preschool; Electromyography; Female; Gait; Humans; Injections, Intramuscular; Lower Extremity; Male; Muscle Spasticity; Neuromuscular Agents; Blockade; Phenol; Treatment Outcome}, month = Apr, number = 4, pages = {284--291}, pii = {00002060-200404000-00008}, pmid = {15024330}, timestamp = {2014-07-19T21:56:27.000+0200}, title = {Clinical effects of botulinum toxin A and phenol block on gait in children with cerebral palsy.}, username = {ar0berts}, volume = 83, year = 2004 }