%0 Journal Article %1 Kalis2001 %A Kalis, V. %A Turek, J. %A Hudec, A. %A Rokyta, P. %A Rokyta, Z. %A Mejchar, B. %D 2001 %J Ceska Gynekol %K Amniotic Fluid; Brain Damage, Chronic; Cerebral Palsy; Chorioamnionitis; Female; Humans; Infant, Newborn; Leukomalacia, Periventricular; Meconium; Placenta; Pregnancy %N 5 %P 369--377 %T Meconium and postnatal neurologic handicaps %V 66 %X OBJECTIVE: A review of meconium pathophysiology and its contribution to the incidence of postnatal neurological handicap. DESIGN: Reviewed article. SETTING: Department of Gynaecology and Obstetrics, Charles University and Faculty Hospital Plzen, Czech Republic. SUBJECT AND METHOD: Meconium can be a cause of infant neurological handicap. Two main pathogenetic pathways are mentioned. 1. Meconium (and its components: bile acids) may have a direct vasoconstrictive effect on umbilical and placental vessels. This way still remains controversial. 2. Meconium as a possible cause of intraamniotic infection results in a release of fetal cytokines (TNF alpha, IL-1 beta, IL-6), which can damage myelinogenesis in periventricular white matter. RESULTS: Meconium in premature labour is a higher risk factor compared to term delivery. 41\% of premature infants were diagnosed as having CP when meconium was present compared to 10\% in the same group with clear amniotic fluid. The incidence in term pregnancy with meconium present is 0.4\% compared to 0.3\% in a population without any obstetrical risk. CONCLUSION: Ultrasonographically found periventricular leukomalacia is the most reliable sign of subsequent cerebral palsy or other neurological sequelae.

@article{Kalis2001, abstract = {OBJECTIVE: A review of meconium pathophysiology and its contribution to the incidence of postnatal neurological handicap. DESIGN: Reviewed article. SETTING: Department of Gynaecology and Obstetrics, Charles University and Faculty Hospital Plzen, Czech Republic. SUBJECT AND METHOD: Meconium can be a cause of infant neurological handicap. Two main pathogenetic pathways are mentioned. 1. Meconium (and its components: bile acids) may have a direct vasoconstrictive effect on umbilical and placental vessels. This way still remains controversial. 2. Meconium as a possible cause of intraamniotic infection results in a release of fetal cytokines (TNF alpha, IL-1 beta, IL-6), which can damage myelinogenesis in periventricular white matter. RESULTS: Meconium in premature labour is a higher risk factor compared to term delivery. 41\% of premature infants were diagnosed as having CP when meconium was present compared to 10\% in the same group with clear amniotic fluid. The incidence in term pregnancy with meconium present is 0.4\% compared to 0.3\% in a population without any obstetrical risk. CONCLUSION: Ultrasonographically found periventricular leukomalacia is the most reliable sign of subsequent cerebral palsy or other neurological sequelae.}, added-at = {2014-07-19T20:31:38.000+0200}, author = {Kalis, V. and Turek, J. and Hudec, A. and Rokyta, P. and Rokyta, Z. and Mejchar, B.}, biburl = {https://www.bibsonomy.org/bibtex/228830a9bfbb54d5061991648c641f5f2/ar0berts}, groups = {public}, interhash = {7e35e79b9babda47b6f7c2f9bb7c2671}, intrahash = {28830a9bfbb54d5061991648c641f5f2}, journal = {Ceska Gynekol}, keywords = {Amniotic Fluid; Brain Damage, Chronic; Cerebral Palsy; Chorioamnionitis; Female; Humans; Infant, Newborn; Leukomalacia, Periventricular; Meconium; Placenta; Pregnancy}, month = Sep, number = 5, pages = {369--377}, pmid = {11732239}, timestamp = {2014-07-19T20:31:38.000+0200}, title = {[Meconium and postnatal neurologic handicaps]}, username = {ar0berts}, volume = 66, year = 2001 }