%0 Journal Article %1 limamorales2021effectiveness %A Lima-Morales, René %A Méndez-Hernández, Pablo %A Flores, Yvonne N. %A Osorno-Romero, Patricia %A Sancho-Hernández, Christian Ronal %A Cuecuecha-Rugerio, Elizabeth %A Nava-Zamora, Adrián %A Hernández-Galdamez, Diego Rolando %A Romo-Dueñas, Daniela Karola %A Salmerón, Jorge %D 2021 %J International Journal of Infectious Diseases %K covid-19 ivermectin %P 598-605 %R https://doi.org/10.1016/j.ijid.2021.02.014 %T Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico %U https://www.sciencedirect.com/science/article/pii/S1201971221001004 %V 105 %X Objective There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. Design and methods A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18–80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment. Results Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group. Conclusions TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.

@article{limamorales2021effectiveness, abstract = {Objective There is an urgent need for effective treatments to prevent or attenuate lung and systemic inflammation, endotheliitis, and thrombosis related to COVID-19. This study aimed to assess the effectiveness of a multidrug-therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid ("TNR4" therapy) to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. Design and methods A comparative effectiveness study was performed among 768 confirmed SARS-CoV-2 cases aged 18–80 years, who received ambulatory care at the Ministry of Health of Tlaxcala. A total of 481 cases received the TNR4 therapy, while 287 received another treatment (comparison group). All participants received home visits and/or phone calls for clinical evaluation during the 14 days after enrollment. Results Nearly 85% of cases who received the TNR4 recovered within 14 days compared to 59% in the comparison group. The likelihood of recovery within 14 days was 3.4 times greater among the TNR4 group than in the comparison group. Patients treated with TNR4 had a 75% and 81% lower risk of being hospitalized or death, respectively, than the comparison group. Conclusions TNR4 therapy improved recovery and prevented the risk of hospitalization and death among ambulatory COVID-19 cases.}, added-at = {2021-04-26T17:49:18.000+0200}, author = {Lima-Morales, René and Méndez-Hernández, Pablo and Flores, Yvonne N. and Osorno-Romero, Patricia and Sancho-Hernández, Christian Ronal and Cuecuecha-Rugerio, Elizabeth and Nava-Zamora, Adrián and Hernández-Galdamez, Diego Rolando and Romo-Dueñas, Daniela Karola and Salmerón, Jorge}, biburl = {https://www.bibsonomy.org/bibtex/2e3cc462e3a332b14450628fe48110435/fordham1}, description = {Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico - ScienceDirect}, doi = {https://doi.org/10.1016/j.ijid.2021.02.014}, interhash = {8454581a0f63320c2924d66f4355cc36}, intrahash = {e3cc462e3a332b14450628fe48110435}, issn = {1201-9712}, journal = {International Journal of Infectious Diseases}, keywords = {covid-19 ivermectin}, pages = {598-605}, timestamp = {2021-04-26T17:49:18.000+0200}, title = {Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico}, url = {https://www.sciencedirect.com/science/article/pii/S1201971221001004}, volume = 105, year = 2021 }