%0 Journal Article %1 Gibson2006 %A Gibson, Catherine S %A MacLennan, Alastair H %A Goldwater, Paul N %A Haan, Eric A %A Priest, Kevin %A Dekker, Gustaaf A %A Group, South Australian Cerebral Palsy Research %D 2006 %J Am J Obstet Gynecol %K Case-Control Studies; Cerebral Palsy; Humans; Infant, Newborn; Mannose-Binding Lectin; Polymorphism, Genetic; Tumor Necrosis Factor-alpha %N 3 %P 674.e1--674.11 %T The association between inherited cytokine polymorphisms and cerebral palsy. %V 194 %X OBJECTIVE: The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. STUDY DESIGN: This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor-alpha-308, mannose-binding lectin-221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. RESULTS: At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95\% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor-alpha (odds ratio, 1.82; 95\% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95\% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon-1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95\% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor-alpha was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95\% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95\% CI, 1.02-1.84). CONCLUSION: Carriage of polymorphisms in the tumor necrosis factor-alpha and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.

@article{Gibson2006, abstract = {OBJECTIVE: The purpose of this study was to investigate associations between inherited cytokine polymorphisms and cerebral palsy. STUDY DESIGN: This was a case-control study that used DNA from the newborn infant screening cards of 443 white infants with cerebral palsy and 883 white control infants to test for the following cytokine polymorphisms: tumor necrosis factor-alpha-308, mannose-binding lectin-221, and 3 polymorphisms in exon-1 of the mannose-binding lectin gene at codon-52, -54, and -57. RESULTS: At all gestational ages mannose-binding lectin codon-54 increased the risk of the development of diplegia (homozygous or heterozygous odds ratio, 1.55; 95\% CI, 1.03-2.32). For babies who were born at term, the risk of the development of quadriplegia was associated with heterozygous tumor necrosis factor-alpha (odds ratio, 1.82; 95\% CI, 1.04-3.15), and mannose-binding lectin codon-54 was associated with diplegia (homozygous or heterozygous odds ratio, 2.12; 95\% CI, 1.10-4.05). The presence of any polymorphism in mannose-binding lectin exon-1 at term approximately doubled the risk of the development of diplegia (odds ratio, 1.94; 95\% CI, 1.05-3.62). Homozygous or heterozygous tumor necrosis factor-alpha was associated with hemiplegia for babies who were born at <32 weeks of gestation (odds ratio, 2.38; 95\% CI, 1.02-5.58). Overall, the presence of any cytokine polymorphism was associated with cerebral palsy (odds ratio, 1.37; 95\% CI, 1.02-1.84). CONCLUSION: Carriage of polymorphisms in the tumor necrosis factor-alpha and mannose-binding lectin genes are associated with an increased risk of cerebral palsy.}, added-at = {2014-07-19T19:31:42.000+0200}, author = {Gibson, Catherine S and MacLennan, Alastair H and Goldwater, Paul N and Haan, Eric A and Priest, Kevin and Dekker, Gustaaf A and Group, South Australian Cerebral Palsy Research}, biburl = {https://www.bibsonomy.org/bibtex/2a9292a7d1977916242ca253f7b59ce56/ar0berts}, groups = {public}, interhash = {85c3ba11fd4f58b50ea271f5fd82a407}, intrahash = {a9292a7d1977916242ca253f7b59ce56}, journal = {Am J Obstet Gynecol}, keywords = {Case-Control Studies; Cerebral Palsy; Humans; Infant, Newborn; Mannose-Binding Lectin; Polymorphism, Genetic; Tumor Necrosis Factor-alpha}, month = Mar, number = 3, pages = {674.e1--674.11}, pmid = {16522396}, timestamp = {2014-07-19T19:31:42.000+0200}, title = {The association between inherited cytokine polymorphisms and cerebral palsy.}, username = {ar0berts}, volume = 194, year = 2006 }