The genesis of new cells, including neurons, in the adult human brain
has not yet been demonstrated. This study was undertaken to investigate
whether neurogenesis occurs in the adult human brain, in regions
previously identified as neurogenic in adult rodents and monkeys.
Human brain tissue was obtained postmortem from patients who had
been treated with the thymidine analog, bromodeoxyuridine (BrdU),
that labels DNA during the S phase. Using immunofluorescent labeling
for BrdU and for one of the neuronal markers, NeuN, calbindin or
neuron specific enolase (NSE), we demonstrate that new neurons, as
defined by these markers, are generated from dividing progenitor
cells in the dentate gyrus of adult humans. Our results further indicate
that the human hippocampus retains its ability to generate neurons
throughout life.
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%0 Journal Article
%1 Eriksson1998
%A Eriksson, P S
%A Perfilieva, E
%A Björk-Eriksson, T
%A Alborn, A M
%A Nordborg, C
%A Peterson, D A
%A Gage, Fred H
%D 1998
%J Nature medicine
%K Acidic Adult,Animals,Astrocytes,Astrocytes: Cells,Stem Cells: D-Dependent,Vitamin D-Dependent: Fibrillary Gyrus,Dentate Gyrus: Hydratase,Phosphopyruvate Hydratase: Markers,Biological Markers: Protein,DNA,DNA: Protein,Glial Protein: Proteins,Nerve Proteins: Regeneration,Nerve Tissue anal analysis,Bromodeoxyuridine,Calcium-Binding analysis,Haplorhini,Hippocampus,Hippocampus: analysis,Neurons,Neurons: analysis,Rodentia,Stem biosynthesis,Dentate cytology,Astrocytes: cytology,Dentate cytology,Hippocampus: cytology,Neurons: cytology,Stem pathology,Astrocytes: pathology,Dentate pathology,Hippocampus: pathology,Neurons: pathology,Stem physiology,Biological physiology,Glial physiology,Humans,Nerve physiology,Phosphopyruvate physiology,Vitamin
%N 11
%P 1313--7
%R 10.1038/3305
%T Neurogenesis in the adult human hippocampus
%U http://www.ncbi.nlm.nih.gov/pubmed/19714567
%V 4
%X The genesis of new cells, including neurons, in the adult human brain
has not yet been demonstrated. This study was undertaken to investigate
whether neurogenesis occurs in the adult human brain, in regions
previously identified as neurogenic in adult rodents and monkeys.
Human brain tissue was obtained postmortem from patients who had
been treated with the thymidine analog, bromodeoxyuridine (BrdU),
that labels DNA during the S phase. Using immunofluorescent labeling
for BrdU and for one of the neuronal markers, NeuN, calbindin or
neuron specific enolase (NSE), we demonstrate that new neurons, as
defined by these markers, are generated from dividing progenitor
cells in the dentate gyrus of adult humans. Our results further indicate
that the human hippocampus retains its ability to generate neurons
throughout life.
@article{Eriksson1998,
abstract = {The genesis of new cells, including neurons, in the adult human brain
has not yet been demonstrated. This study was undertaken to investigate
whether neurogenesis occurs in the adult human brain, in regions
previously identified as neurogenic in adult rodents and monkeys.
Human brain tissue was obtained postmortem from patients who had
been treated with the thymidine analog, bromodeoxyuridine (BrdU),
that labels DNA during the S phase. Using immunofluorescent labeling
for BrdU and for one of the neuronal markers, NeuN, calbindin or
neuron specific enolase (NSE), we demonstrate that new neurons, as
defined by these markers, are generated from dividing progenitor
cells in the dentate gyrus of adult humans. Our results further indicate
that the human hippocampus retains its ability to generate neurons
throughout life.},
added-at = {2011-03-27T17:20:41.000+0200},
author = {Eriksson, P S and Perfilieva, E and Bj\"{o}rk-Eriksson, T and Alborn, A M and Nordborg, C and Peterson, D A and Gage, Fred H},
biburl = {https://www.bibsonomy.org/bibtex/2789a1c238a3d292340485ac64ca81ec2/yevb0},
doi = {10.1038/3305},
interhash = {88c641794966ac90a7c15422fb923fab},
intrahash = {789a1c238a3d292340485ac64ca81ec2},
issn = {1078-8956},
journal = {Nature medicine},
keywords = {Acidic Adult,Animals,Astrocytes,Astrocytes: Cells,Stem Cells: D-Dependent,Vitamin D-Dependent: Fibrillary Gyrus,Dentate Gyrus: Hydratase,Phosphopyruvate Hydratase: Markers,Biological Markers: Protein,DNA,DNA: Protein,Glial Protein: Proteins,Nerve Proteins: Regeneration,Nerve Tissue anal analysis,Bromodeoxyuridine,Calcium-Binding analysis,Haplorhini,Hippocampus,Hippocampus: analysis,Neurons,Neurons: analysis,Rodentia,Stem biosynthesis,Dentate cytology,Astrocytes: cytology,Dentate cytology,Hippocampus: cytology,Neurons: cytology,Stem pathology,Astrocytes: pathology,Dentate pathology,Hippocampus: pathology,Neurons: pathology,Stem physiology,Biological physiology,Glial physiology,Humans,Nerve physiology,Phosphopyruvate physiology,Vitamin},
month = nov,
number = 11,
pages = {1313--7},
pmid = {9809557},
timestamp = {2011-03-27T17:20:49.000+0200},
title = {Neurogenesis in the adult human hippocampus},
url = {http://www.ncbi.nlm.nih.gov/pubmed/19714567},
volume = 4,
year = 1998
}