%0 Journal Article %1 RN22 %A Areche, C. %A San-Martin, A. %A Rovirosa, J. %A Sepulveda, B. %D 2011 %J Natural Product Communications %K activity, dqcauchile epitaondiol, flabelliforme gastroprotective sargaol, stypopodium %N 8 %P 1073-1074 %R 10.1177/1934578X1100600805 %T Gastroprotective Activity of Epitaondiol and Sargaol %U /brokenurl#<Go to ISI>://WOS:000294035300005 %V 6 %X The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.

@article{RN22, abstract = {The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice.}, added-at = {2019-12-04T03:57:35.000+0100}, author = {Areche, C. and San-Martin, A. and Rovirosa, J. and Sepulveda, B.}, biburl = {https://www.bibsonomy.org/bibtex/2cc36d6fc7829df63a34e230f1bf11c28/dqcauchile}, doi = {10.1177/1934578X1100600805}, interhash = {8e9b2eb5d023530018fc3372167a62d1}, intrahash = {cc36d6fc7829df63a34e230f1bf11c28}, issn = {1934-578x}, journal = {Natural Product Communications}, keywords = {activity, dqcauchile epitaondiol, flabelliforme gastroprotective sargaol, stypopodium}, number = 8, pages = {1073-1074}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Gastroprotective Activity of Epitaondiol and Sargaol}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000294035300005}, volume = 6, year = 2011 }