%0 Journal Article %1 Nagel.2005b %A Nagel, E. %A Vilser, W. %A Lanzl, I. M. %D 2005 %J Current Eye Research %K (Carbonic (Ophthalmic (Sulfonamides);0 (Thiophenes);9JDX055TW1 (dorzolamide);Aged;Blood 0 Aged;Muscle, Anhydrase Artery/*physiopathology;Sulfonamides/*therapeutic Hypertension/physiopathology;Ophthalmic Inhibitors);0 Inhibitors/*therapeutic Open-Angle/*drug Pressure;Carbonic Pressure;Male;Middle Smooth, Solutions);0 Solutions;Retinal Vascular/physiopathology;Ocular WViCo therapy/*physiopathology;Homeostasis/physiology;Humans;*Intraocular use;Female;Glaucoma, use;Thiophenes/*therapeutic use;Vasodilation %N 2 %P 129--137 %R 10.1080/02713680490904133 %T Dorzolamide influences the autoregulation of major retinal vessels caused by artificial intraocular pressure elevation in patients with POAG: a clinical study %V 30 %X PURPOSE: The study investigated whether dorzolamide influences the autoregulatory behavior of major retinal arterioles in glaucoma patients via a moderate perfusion pressure reduction. METHODS: The study included one eye each of 12 untreated patients with a primary open-angle glaucoma (POAG) (age 60.8 +/- 8.3, IOP 22.3 +/- 6.5 mmHg). Changes in the diameter of a retinal artery segment before (120 s), during (100 s), and after (380 s) artificial IOP elevation to 38 mmHg for 100 s were recorded continuously by means of a Retinal Vessel Analyzer. The measurement was repeated after 4-week treatment with dorzolamide eye drops t.i.d. RESULTS: Ocular perfusion pressure (mmHg) was reduced by the intraocular pressure (IOP) elevation from 58 (+/- 10) to 41 (+/- 11) in the pretreatment examination and from 60 (+/- 8) to 40 (+/- 8) posttreatment (differences between the examinations n.s.). Before IOP elevation, the arterial diameter was found to be +1.7 +/- 3.5\% greater in the posttreated eyes than in the pretreated eyes (p < 0.02). During IOP elevation, the arterial diameter decreased by -1.8\% +/- 3.8 in the pretreated eyes, whereas dilatation by +1.4\% +/- 2.5 was observed in the posttreated eyes (p = 0.02). At the end of the observation period following IOP elevation, the vessel diameter in the pretreated eyes had increased by +1.8\% +/- 4.2, whereas in the posttreated eyes it had decreased by -1.7\% +/- 3.0. On average, dorzolamide reduced IOP by -5.6 mmHg (p = 0.001). CONCLUSIONS: The arterial diameter dilatation during IOP elevation in dorzolamide-treated eyes could be an accelerated counter-regulation on the induced elevated IOP and could constitute an additional therapeutic effect.

@article{Nagel.2005b, abstract = {PURPOSE: The study investigated whether dorzolamide influences the autoregulatory behavior of major retinal arterioles in glaucoma patients via a moderate perfusion pressure reduction. METHODS: The study included one eye each of 12 untreated patients with a primary open-angle glaucoma (POAG) (age 60.8 +/- 8.3, IOP 22.3 +/- 6.5 mmHg). Changes in the diameter of a retinal artery segment before (120 s), during (100 s), and after (380 s) artificial IOP elevation to 38 mmHg for 100 s were recorded continuously by means of a Retinal Vessel Analyzer. The measurement was repeated after 4-week treatment with dorzolamide eye drops t.i.d. RESULTS: Ocular perfusion pressure (mmHg) was reduced by the intraocular pressure (IOP) elevation from 58 (+/- 10) to 41 (+/- 11) in the pretreatment examination and from 60 (+/- 8) to 40 (+/- 8) posttreatment (differences between the examinations n.s.). Before IOP elevation, the arterial diameter was found to be +1.7 +/- 3.5{\%} greater in the posttreated eyes than in the pretreated eyes (p < 0.02). During IOP elevation, the arterial diameter decreased by -1.8{\%} +/- 3.8 in the pretreated eyes, whereas dilatation by +1.4{\%} +/- 2.5 was observed in the posttreated eyes (p = 0.02). At the end of the observation period following IOP elevation, the vessel diameter in the pretreated eyes had increased by +1.8{\%} +/- 4.2, whereas in the posttreated eyes it had decreased by -1.7{\%} +/- 3.0. On average, dorzolamide reduced IOP by -5.6 mmHg (p = 0.001). CONCLUSIONS: The arterial diameter dilatation during IOP elevation in dorzolamide-treated eyes could be an accelerated counter-regulation on the induced elevated IOP and could constitute an additional therapeutic effect.}, added-at = {2013-10-10T21:29:09.000+0200}, author = {Nagel, E. and Vilser, W. and Lanzl, I. M.}, biburl = {https://www.bibsonomy.org/bibtex/22f8b6e66b872dc7c2b7aecd2321e3bb0/imedos}, doi = {10.1080/02713680490904133}, interhash = {9d0a549b4c804b1ee243d58f094c4ff6}, intrahash = {2f8b6e66b872dc7c2b7aecd2321e3bb0}, issn = {0271-3683}, journal = {Current Eye Research}, keywords = {(Carbonic (Ophthalmic (Sulfonamides);0 (Thiophenes);9JDX055TW1 (dorzolamide);Aged;Blood 0 Aged;Muscle, Anhydrase Artery/*physiopathology;Sulfonamides/*therapeutic Hypertension/physiopathology;Ophthalmic Inhibitors);0 Inhibitors/*therapeutic Open-Angle/*drug Pressure;Carbonic Pressure;Male;Middle Smooth, Solutions);0 Solutions;Retinal Vascular/physiopathology;Ocular WViCo therapy/*physiopathology;Homeostasis/physiology;Humans;*Intraocular use;Female;Glaucoma, use;Thiophenes/*therapeutic use;Vasodilation}, number = 2, pages = {129--137}, timestamp = {2013-10-11T01:11:02.000+0200}, title = {Dorzolamide influences the autoregulation of major retinal vessels caused by artificial intraocular pressure elevation in patients with POAG: a clinical study}, volume = 30, year = 2005 }