%0 Journal Article %1 Costeff2004 %A Costeff, H. %D 2004 %J Ann Hum Genet %K Adult; Birth Injuries; Brain Cerebral Palsy; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Premature Birth; Risk Factors; Sweden %N Pt 5 %P 515--520 %R 10.1046/j.1529-8817.2004.00105.x %T Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden. %U http://dx.doi.org/10.1046/j.1529-8817.2004.00105.x %V 68 %X Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40\% of etiologically undiagnosed cases of CP in the community (48\% of those born at term and 24\% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60\% of maturely born hemiplegics, 45\% of maturely born spastic diplegics, 32\% of premature spastic diplegics and virtually all cases of pure ataxia. About 23\% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37\% is characterized by a single risk factor, usually perinatal.

@article{Costeff2004, abstract = {Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40\% of etiologically undiagnosed cases of CP in the community (48\% of those born at term and 24\% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60\% of maturely born hemiplegics, 45\% of maturely born spastic diplegics, 32\% of premature spastic diplegics and virtually all cases of pure ataxia. About 23\% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37\% is characterized by a single risk factor, usually perinatal.}, added-at = {2014-07-19T19:16:26.000+0200}, author = {Costeff, H.}, biburl = {https://www.bibsonomy.org/bibtex/230523a363bdae7b858096fdb078a6f37/ar0berts}, doi = {10.1046/j.1529-8817.2004.00105.x}, groups = {public}, interhash = {9fd02eb563ea368f95ef86689edfb171}, intrahash = {30523a363bdae7b858096fdb078a6f37}, journal = {Ann Hum Genet}, keywords = {Adult; Birth Injuries; Brain Cerebral Palsy; Cohort Studies; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Premature Birth; Risk Factors; Sweden}, month = Sep, number = {Pt 5}, pages = {515--520}, pii = {AHG105}, pmid = {15469428}, timestamp = {2014-07-19T19:16:26.000+0200}, title = {Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden.}, url = {http://dx.doi.org/10.1046/j.1529-8817.2004.00105.x}, username = {ar0berts}, volume = 68, year = 2004 }