%0 Journal Article %1 Marr2004 %A Marr, Kieren A. %A Boeckh, Michael %A Carter, Rachel A. %A Kim, Hyung Woo %A Corey, Lawrence %D 2004 %J Clin Infect Dis %K fungal dosing drug pneumonia %N 6 %P 797--802 %R 10.1086/423380 %T Combination antifungal therapy for invasive aspergillosis. %U http://dx.doi.org/10.1086/423380 %V 39 %X Aspergillosis therapy with amphotericin, azoles, or echinocandins is associated with substantial mortality, ranging from 30\% to 80\%, depending on the stage of infection and the host's underlying disease. The results of in vitro studies and animal models suggest that combination therapy with azoles and echinocandins may have additive activity against Aspergillus species.We evaluated the outcomes of patients with aspergillosis who experienced failure of initial therapy with amphotericin B formulations and received either voriconazole (n=31) or a combination of voriconazole and caspofungin (n=16) for salvage therapy.The combination of voriconazole and caspofungin was associated with improved 3-month survival rate, compared with voriconazole alone (hazard ratio HR, 0.42; 95\% confidence interval CI, 0.17-1.1; P=.048). In multivariable models, salvage therapy with the combination of voriconazole and caspofungin was associated with reduced mortality, compared with therapy with voriconazole (HR, 0.28; 95\% CI, 0.28-0.92; P=.011), independent of other prognostic variables (e.g., receipt of transplant and type of conditioning therapy). The probability of death due to aspergillosis was lowest in patients who received the combination regimen.Randomized trials are warranted to determine whether this combination should be used as primary therapy for aspergillosis.

@article{Marr2004, abstract = {Aspergillosis therapy with amphotericin, azoles, or echinocandins is associated with substantial mortality, ranging from 30\% to 80\%, depending on the stage of infection and the host's underlying disease. The results of in vitro studies and animal models suggest that combination therapy with azoles and echinocandins may have additive activity against Aspergillus species.We evaluated the outcomes of patients with aspergillosis who experienced failure of initial therapy with amphotericin B formulations and received either voriconazole (n=31) or a combination of voriconazole and caspofungin (n=16) for salvage therapy.The combination of voriconazole and caspofungin was associated with improved 3-month survival rate, compared with voriconazole alone (hazard ratio [HR], 0.42; 95\% confidence interval [CI], 0.17-1.1; P=.048). In multivariable models, salvage therapy with the combination of voriconazole and caspofungin was associated with reduced mortality, compared with therapy with voriconazole (HR, 0.28; 95\% CI, 0.28-0.92; P=.011), independent of other prognostic variables (e.g., receipt of transplant and type of conditioning therapy). The probability of death due to aspergillosis was lowest in patients who received the combination regimen.Randomized trials are warranted to determine whether this combination should be used as primary therapy for aspergillosis.}, added-at = {2013-03-30T03:34:06.000+0100}, author = {Marr, Kieren A. and Boeckh, Michael and Carter, Rachel A. and Kim, Hyung Woo and Corey, Lawrence}, biburl = {https://www.bibsonomy.org/bibtex/2d1f2ca680726ef5b19e1f111e797cab0/aorchid}, description = {see page 93 of notebook 00002. Salvage Rx trial. Small numbers but suggests it is better to use combination of vori + caspo instead of vori alone for salvage from AmB Rx initially.}, doi = {10.1086/423380}, file = {:ID_General/Fungus_most/ClinInfectDis.39.797.pdf:PDF}, groups = {public}, institution = {Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. kmarr@fhcrc.org}, interhash = {a2d4bc8c47dfd599e4a8c6c093053f87}, intrahash = {d1f2ca680726ef5b19e1f111e797cab0}, journal = {Clin Infect Dis}, keywords = {fungal dosing drug pneumonia}, language = {eng}, medline-pst = {ppublish}, month = Sep, number = 6, pages = {797--802}, pii = {CID33086}, pmid = {15472810}, timestamp = {2013-03-30T03:34:06.000+0100}, title = {Combination antifungal therapy for invasive aspergillosis.}, url = {http://dx.doi.org/10.1086/423380}, username = {aorchid}, volume = 39, year = 2004 }