%0 Journal Article %1 rosenstein_changing_1999 %A Rosenstein, N E %A Perkins, B A %A Stephens, D S %A Lefkowitz, L %A Cartter, M L %A Danila, R %A Cieslak, P %A Shutt, K A %A Popovic, T %A Schuchat, A %A Harrison, L H %A Reingold, A L %D 1999 %J The Journal of Infectious Diseases %K 80 Adolescent, Adult, Age Aged, Child, Distribution, Electrophoresis, Enzymes, Female, Humans, Incidence, Infant, Infections, Male, Meningococcal Middle Neisseria Newborn, Population Preschool, Prevalence, Seasons, Serotyping, Sex States Surveillance, United and meningitidis, over, %N 6 %P 1894--901 %R 10.1086/315158 %T The changing epidemiology of meningococcal disease in the United States, 1992-1996 %U http://www.ncbi.nlm.nih.gov/pubmed/10558946 %V 180 %X New meningococcal vaccines are undergoing clinical trials, and changes in the epidemiologic features of meningococcal disease will affect their use. Active laboratory-based, population-based US surveillance for meningococcal disease during 1992-1996 was used to project that 2400 cases of meningococcal disease occurred annually. Incidence was highest in infants; however, 32\% of cases occurred in persons \textgreater/=30 years of age. Serogroup C caused 35\% of cases; serogroup B, 32\%; and serogroup Y, 26\%. Increasing age (relative risk RR, 1.01 per year), having an isolate obtained from blood (RR, 4.5), and serogroup C (RR, 1.6) were associated with increased case fatality. Among serogroup B isolates, the most commonly expressed serosubtype was P1.15; 68\% of isolates expressed 1 of the 6 most common serosubtypes. Compared with cases occurring in previous years, recent cases are more likely to be caused by serogroup Y and to occur among older age groups. Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution.

@article{rosenstein_changing_1999, abstract = {New meningococcal vaccines are undergoing clinical trials, and changes in the epidemiologic features of meningococcal disease will affect their use. Active laboratory-based, population-based {US} surveillance for meningococcal disease during 1992-1996 was used to project that 2400 cases of meningococcal disease occurred annually. Incidence was highest in infants; however, 32\% of cases occurred in persons {\textgreater}/=30 years of age. Serogroup C caused 35\% of cases; serogroup B, 32\%; and serogroup Y, 26\%. Increasing age (relative risk {[RR],} 1.01 per year), having an isolate obtained from blood {(RR,} 4.5), and serogroup C {(RR,} 1.6) were associated with increased case fatality. Among serogroup B isolates, the most commonly expressed serosubtype was P1.15; 68\% of isolates expressed 1 of the 6 most common serosubtypes. Compared with cases occurring in previous years, recent cases are more likely to be caused by serogroup Y and to occur among older age groups. Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Rosenstein, N E and Perkins, B A and Stephens, D S and Lefkowitz, L and Cartter, M L and Danila, R and Cieslak, P and Shutt, K A and Popovic, T and Schuchat, A and Harrison, L H and Reingold, A L}, biburl = {https://www.bibsonomy.org/bibtex/27d9387ec8696fc7223f510e0f7211562/jelias}, doi = {10.1086/315158}, interhash = {a3b2da5c03cd1282de8ac12fdc020d84}, intrahash = {7d9387ec8696fc7223f510e0f7211562}, issn = {0022-1899}, journal = {The Journal of Infectious Diseases}, keywords = {80 Adolescent, Adult, Age Aged, Child, Distribution, Electrophoresis, Enzymes, Female, Humans, Incidence, Infant, Infections, Male, Meningococcal Middle Neisseria Newborn, Population Preschool, Prevalence, Seasons, Serotyping, Sex States Surveillance, United and meningitidis, over,}, month = dec, note = {{PMID:} 10558946}, number = 6, pages = {1894--901}, timestamp = {2011-03-11T10:06:14.000+0100}, title = {The changing epidemiology of meningococcal disease in the United States, 1992-1996}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10558946}, volume = 180, year = 1999 }