%0 Journal Article %1 WOS:000411542300025 %A Vinhote, Juliana Freire Chagas %A Lima, Danya Bandeira %A de Menezes, Ramon Roseo Paula Pessoa Bezerra %A Mello, Clarissa Perdigao %A de Souza, Bibiana Monson %A Havt, Alexandre %A Palma, Mario Sergio %A dos Santos, Ricardo Pires %A de Albuquerque, Eudenilson Lins %A Freire, Valder Nogueira %A Martins, Alice Maria Costa %C THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND %D 2017 %I PERGAMON-ELSEVIER SCIENCE LTD %J TOXICON %K Mastoparan} Molecular Wasp agents; docking; venom; {Antiparasitic %P 168-172 %R 10.1016/j.toxicon.2017.08.002 %T Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH %V 137 %X Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.

@article{WOS:000411542300025, abstract = {Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, author = {Vinhote, Juliana Freire Chagas and Lima, Danya Bandeira and de Menezes, Ramon Roseo Paula Pessoa Bezerra and Mello, Clarissa Perdigao and de Souza, Bibiana Monson and Havt, Alexandre and Palma, Mario Sergio and dos Santos, Ricardo Pires and de Albuquerque, Eudenilson Lins and Freire, Valder Nogueira and Martins, Alice Maria Costa}, biburl = {https://www.bibsonomy.org/bibtex/281eae9954cb1bb7cf7212084c051de8c/ppgfis_ufc_br}, doi = {10.1016/j.toxicon.2017.08.002}, interhash = {a900aff2fb2832e8ac3904ed2c410081}, intrahash = {81eae9954cb1bb7cf7212084c051de8c}, issn = {0041-0101}, journal = {TOXICON}, keywords = {Mastoparan} Molecular Wasp agents; docking; venom; {Antiparasitic}, pages = {168-172}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH}, tppubtype = {article}, volume = 137, year = 2017 }