%0 Journal Article %1 Duff.2005 %A Duff, S. E. %A Saunders, M. %A McCredie, V. %A Kumar, S. %A O'Dwyer, S. T. %A Jayson, G. C. %D 2005 %J Clin.Oncol.(R.Coll.Radiol.) %K A Adult Aged Assay C Cohort Colorectal D Endothelial Enzyme-Linked Factor Factors Female Growth Human Humans Immunosorbent Lymphatic Male Metastasis Middle Neoplasms Studies Vascular blood diagnosis methods pathology protein %N 5 %P 367-371 %T Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer %U PM:16097569 %V 17 %X AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml range, 4.9-51.9 vs 9

@article{Duff.2005, abstract = {AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml [range, 4.9-51.9] vs 9}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Duff, S. E. and Saunders, M. and McCredie, V. and Kumar, S. and O'Dwyer, S. T. and Jayson, G. C.}, biburl = {https://www.bibsonomy.org/bibtex/2284adf235756fcf696d5bd2fcd64cf9a/kanefendt}, interhash = {aae2e029bb658d9c0b2ec75680ed3247}, intrahash = {284adf235756fcf696d5bd2fcd64cf9a}, journal = {Clin.Oncol.(R.Coll.Radiol.)}, keywords = {A Adult Aged Assay C Cohort Colorectal D Endothelial Enzyme-Linked Factor Factors Female Growth Human Humans Immunosorbent Lymphatic Male Metastasis Middle Neoplasms Studies Vascular blood diagnosis methods pathology protein}, number = 5, pages = {367-371}, timestamp = {2010-02-05T11:28:42.000+0100}, title = {Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer}, url = {PM:16097569}, volume = 17, year = 2005 }