%0 Book Section %1 statphys23_0288 %A Huber, G. %A Li, G. %A Wen, Q. %A Tang, J. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K chemotaxis first-passage flagellar molecular motor motors statphys23 time topic-10 %T Dominos, first-passage problems, and dynamic binding in flagellar motor statistics %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=288 %X The flagellar motor of bacteria is perhaps the most elaborate stoichiometric molecular machine engineered by evolution. It harnesses the chemical energy associated with a proton gradient for its rotation (typically hundreds of Hz), while, at longer time scales, stochastically switching between clockwise (CW) and counterclockwise (CCW) rotations. And while the switching of the rotational direction of the flagellar motor plays a crucial role in bacterial chemotaxis, its mechanism remains poorly understood. Here, I'll present recent work on the switch statistics of the flagellar motor of Caulobacter crescentus. I'll show how the interval distribution of the CW and CCW rotation provides insight into the switching, and describe a model that combines first-passage-time theory and dynamic binding to explain the switching mechanism. The model accounts for the motor's dependence on CheYp concentration, and predicts that dynamic binding of CheYp to the switch-complex proteins is the key to the signal amplification of the motor.

@incollection{statphys23_0288, abstract = {The flagellar motor of bacteria is perhaps the most elaborate stoichiometric molecular machine engineered by evolution. It harnesses the chemical energy associated with a proton gradient for its rotation (typically hundreds of Hz), while, at longer time scales, stochastically switching between clockwise (CW) and counterclockwise (CCW) rotations. And while the switching of the rotational direction of the flagellar motor plays a crucial role in bacterial chemotaxis, its mechanism remains poorly understood. Here, I'll present recent work on the switch statistics of the flagellar motor of Caulobacter crescentus. I'll show how the interval distribution of the CW and CCW rotation provides insight into the switching, and describe a model that combines first-passage-time theory and dynamic binding to explain the switching mechanism. The model accounts for the motor's dependence on CheYp concentration, and predicts that dynamic binding of CheYp to the switch-complex proteins is the key to the signal amplification of the motor.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Huber, G. and Li, G. and Wen, Q. and Tang, J.}, biburl = {https://www.bibsonomy.org/bibtex/249424d325984b904ce3f0ea5c1e78914/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {ac4a2188833ccd98c308ec73dd7fbcbc}, intrahash = {49424d325984b904ce3f0ea5c1e78914}, keywords = {chemotaxis first-passage flagellar molecular motor motors statphys23 time topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:16.000+0200}, title = {Dominos, first-passage problems, and dynamic binding in flagellar motor statistics}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=288}, year = 2007 }