%0 Journal Article %1 Murukesh.2009 %A Murukesh, N. %A Dive, C. %A Jayson, G. C. %D 2009 %J Br.J.Cancer %K Blood Growth Health Medical Oncology Plasma Pressure Prospective Research Studies blood identify response %T Biomarkers of angiogenesis and their role in the development of VEGF inhibitors %U PM:20010945 %X Vascular endothelial growth factor (VEGF) has been confirmed as an important therapeutic target in randomised clinical trials in multiple disease settings. However, the extent to which individual patients benefit from VEGF inhibitors is unclear. If we are to optimise the use of these drugs or develop combination regimens that build on this efficacy, it is critical to identify those patients who are likely to benefit, particularly as these agents can be toxic and are expensive. To this end, biomarkers have been evaluated in tissue, in circulation and by imaging. Consistent drug-induced increases in plasma VEGF-A and blood pressure, as well as reductions in soluble VEGF-R2 and dynamic contrast-enhanced MRI parameters have been reported. In some clinical trials, biomarker changes were statistically significant and associated with clinical end points, but there is considerable heterogeneity between studies that are to some extent attributable to methodological issues. On the basis of obser

@article{Murukesh.2009, abstract = {Vascular endothelial growth factor (VEGF) has been confirmed as an important therapeutic target in randomised clinical trials in multiple disease settings. However, the extent to which individual patients benefit from VEGF inhibitors is unclear. If we are to optimise the use of these drugs or develop combination regimens that build on this efficacy, it is critical to identify those patients who are likely to benefit, particularly as these agents can be toxic and are expensive. To this end, biomarkers have been evaluated in tissue, in circulation and by imaging. Consistent drug-induced increases in plasma VEGF-A and blood pressure, as well as reductions in soluble VEGF-R2 and dynamic contrast-enhanced MRI parameters have been reported. In some clinical trials, biomarker changes were statistically significant and associated with clinical end points, but there is considerable heterogeneity between studies that are to some extent attributable to methodological issues. On the basis of obser}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Murukesh, N. and Dive, C. and Jayson, G. C.}, biburl = {https://www.bibsonomy.org/bibtex/2378b226bb2c6e9aa0c051efffabc3223/kanefendt}, interhash = {acc506e3e2e06d222f9e649e377054ad}, intrahash = {378b226bb2c6e9aa0c051efffabc3223}, journal = {Br.J.Cancer}, keywords = {Blood Growth Health Medical Oncology Plasma Pressure Prospective Research Studies blood identify response}, timestamp = {2010-02-05T11:28:53.000+0100}, title = {Biomarkers of angiogenesis and their role in the development of VEGF inhibitors}, url = {PM:20010945}, year = 2009 }