%0 Journal Article %1 McFall-Ngai26022013 %A McFall-Ngai, Margaret %A Hadfield, Michael G. %A Bosch, Thomas C. G. %A Carey, Hannah V. %A Domazet-Lošo, Tomislav %A Douglas, Angela E. %A Dubilier, Nicole %A Eberl, Gerard %A Fukami, Tadashi %A Gilbert, Scott F. %A Hentschel, Ute %A King, Nicole %A Kjelleberg, Staffan %A Knoll, Andrew H. %A Kremer, Natacha %A Mazmanian, Sarkis K. %A Metcalf, Jessica L. %A Nealson, Kenneth %A Pierce, Naomi E. %A Rawls, John F. %A Reid, Ann %A Ruby, Edward G. %A Rumpho, Mary %A Sanders, Jon G. %A Tautz, Diethard %A Wernegreen, Jennifer J. %D 2013 %J Proceedings of the National Academy of Sciences %K bacteria %N 9 %P 3229-3236 %R 10.1073/pnas.1218525110 %T Animals in a bacterial world, a new imperative for the life sciences %U http://www.pnas.org/content/110/9/3229.abstract %V 110 %X In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal–bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal–bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.

@article{McFall-Ngai26022013, abstract = {In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal–bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other’s genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal–bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.}, added-at = {2013-07-08T13:29:17.000+0200}, author = {McFall-Ngai, Margaret and Hadfield, Michael G. and Bosch, Thomas C. G. and Carey, Hannah V. and Domazet-Lošo, Tomislav and Douglas, Angela E. and Dubilier, Nicole and Eberl, Gerard and Fukami, Tadashi and Gilbert, Scott F. and Hentschel, Ute and King, Nicole and Kjelleberg, Staffan and Knoll, Andrew H. and Kremer, Natacha and Mazmanian, Sarkis K. and Metcalf, Jessica L. and Nealson, Kenneth and Pierce, Naomi E. and Rawls, John F. and Reid, Ann and Ruby, Edward G. and Rumpho, Mary and Sanders, Jon G. and Tautz, Diethard and Wernegreen, Jennifer J.}, biburl = {https://www.bibsonomy.org/bibtex/204fc85a08aeb58552384891e4e62a8c5/quantentunnel}, doi = {10.1073/pnas.1218525110}, eprint = {http://www.pnas.org/content/110/9/3229.full.pdf+html}, interhash = {affba6d913cf133ae50f0b8ae00ec2b4}, intrahash = {04fc85a08aeb58552384891e4e62a8c5}, journal = {Proceedings of the National Academy of Sciences}, keywords = {bacteria}, number = 9, pages = {3229-3236}, timestamp = {2013-07-08T13:29:17.000+0200}, title = {Animals in a bacterial world, a new imperative for the life sciences}, url = {http://www.pnas.org/content/110/9/3229.abstract}, volume = 110, year = 2013 }