%0 Journal Article %1 Casci2010Epistasis %A Casci, Tanita %D 2010 %I Nature Publishing Group %J Nature Reviews Genetics %K commentary epistasis %N 8 %P 531 %R 10.1038/nrg2836 %T Epistasis: A network of interactors %U http://dx.doi.org/10.1038/nrg2836 %V 11 %X If, as some believe, a large portion of the heritability of complex phenotypes resides in synthetic gene–gene interactions, how should we look for these genetic modifiers? Two papers now offer different solutions: one uses a network-guided process and the second is based on patterns of gene co-retention in radiation hybrid (RH) lines. Studies in model systems show unequivocally that non-additive gene interactions are pervasive in biology.

@article{Casci2010Epistasis, abstract = {If, as some believe, a large portion of the heritability of complex phenotypes resides in synthetic gene\^{a}€“gene interactions, how should we look for these genetic modifiers? Two papers now offer different solutions: one uses a network-guided process and the second is based on patterns of gene co-retention in radiation hybrid ({RH}) lines. Studies in model systems show unequivocally that non-additive gene interactions are pervasive in biology.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Casci, Tanita}, biburl = {https://www.bibsonomy.org/bibtex/2ba00f617d30875b6cc0cfbbe06798fae/karthikraman}, citeulike-article-id = {7427418}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2836}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2836}, day = 06, doi = {10.1038/nrg2836}, interhash = {b7ce8527ad800578b690e0144150e1f1}, intrahash = {ba00f617d30875b6cc0cfbbe06798fae}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {commentary epistasis}, month = jul, number = 8, pages = 531, posted-at = {2010-07-08 08:42:12}, priority = {2}, publisher = {Nature Publishing Group}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Epistasis: A network of interactors}, url = {http://dx.doi.org/10.1038/nrg2836}, volume = 11, year = 2010 }