Article,
Nanoparticles Mediated Photo Thermal Therapy, A Review of Therapeutic Applications
Central Asian Journal of Theoretical and Applied Science, 4 (12): 285-291 (November 2023)
Abstract
Nanoparticles-mediated photothermal therapy (PTT) has emerged as a promising approach for various therapeutic applications, particularly in the field of cancer therapy. This review presents an overview of the therapeutic applications of nanoparticles in PTT and discusses their unique properties and capabilities. The selective accumulation of nanoparticles in tumor tissues through active targeting strategies allows for enhanced treatment efficacy while minimizing damage to healthy tissues. Nanoparticles exhibit strong light-absorbing properties in the near-infrared (NIR) region, enabling efficient conversion of light into heat and inducing localized hyperthermia. This localized heat leads to tumor cell death through various mechanisms, including protein denaturation, membrane disruption, and oxidative stress. Additionally, nanoparticles can be engineered to carry therapeutic payloads, enabling combination therapies that synergistically enhance tumor cell killing. Despite the potential of nanoparticles-mediated PTT, several challenges need to be addressed. Tumor heterogeneity, optimal nanoparticle design, biocompatibility, toxicity, treatment monitoring, and clinical translation are among the key areas that require further investigation. Overcoming these challenges will facilitate the successful clinical translation of PTT and its integration into standard cancer treatment protocols. Future directions in nanoparticles-mediated PTT involve refining nanoparticle design, exploring new nanomaterials, and improving treatment monitoring techniques. Combination therapies, personalized treatment approaches, and investigations into applications beyond cancer therapy hold promise for future research.
