%0 Journal Article %1 Macaya2017 %A Macaya, Fernando %A Ryan, Nicola %A Salinas, Pablo %A Pocock, Stuart J %D 2017 %J Journal of the American College of Cardiology %K clinicaltrial clinicaltrialdesign coronarystent noninferioritymargin samplesize %N 7 %P 894-903 %R 10.1016/j.jacc.2017.06.039 %T Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials. %U https://linkinghub.elsevier.com/retrieve/pii/S0735109717379275 http://www.ncbi.nlm.nih.gov/pubmed/28797360 %V 70 %X The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of noninferiority trials and then explore some common methodological criticism by analyzing a sample of contemporary coronary stent trials. Finally, the authors give an overall perspective to enhance the design and conduct of future trials.

@article{Macaya2017, abstract = {The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of noninferiority trials and then explore some common methodological criticism by analyzing a sample of contemporary coronary stent trials. Finally, the authors give an overall perspective to enhance the design and conduct of future trials.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Macaya, Fernando and Ryan, Nicola and Salinas, Pablo and Pocock, Stuart J}, biburl = {https://www.bibsonomy.org/bibtex/26a6ab944cd12880eb238cc84084500ff/jepcastel}, doi = {10.1016/j.jacc.2017.06.039}, interhash = {c5d50354e36c965eeccb310f91a0f1ad}, intrahash = {6a6ab944cd12880eb238cc84084500ff}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {clinicaltrial clinicaltrialdesign coronarystent noninferioritymargin samplesize}, month = {8}, note = {Tests d'equivalència; Introductori; CV<br/><br/>Escel·lents gràfics, com en tota la sèrie de la revista JACC}, number = 7, pages = {894-903}, pmid = {28797360}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Challenges in the Design and Interpretation of Noninferiority Trials: Insights From Recent Stent Trials.}, url = {https://linkinghub.elsevier.com/retrieve/pii/S0735109717379275 http://www.ncbi.nlm.nih.gov/pubmed/28797360}, volume = 70, year = 2017 }