Incollection,
A comparative study of the complex transcription-factor gene regulatory networks of E. coli and S. cerevisiae
Abstract Book of the XXIII IUPAP International Conference on Statistical Physics, Genova, Italy, (9-13 July 2007)
Abstract
We present a comparative analysis of two different transcriptional regulatory networks: one for the bacterium Escherichia coli, and one for the budding yeast Saccharomyces cerevisiae.
First, we measure several network properties for the bipartite networks (with unidirectional links from the transcription factors to the regulated genes), as well as for the networks projected to the transcription factors and to the regulated genes. These measurements include the clustering coefficient, the degree distribution, the path length and a coefficient measuring to what degree the nodes with most links in the network are connected among them. Later, we construct random networks with the same degree distributions as those of E. coli and S. cerevisiae, and carry out the same measurements to compare with the original networks. Finally, we tested network robustness by subjecting the original and randomized networks to removal of the most connected nodes, and evaluating the changes.
