%0 Journal Article %1 koelle_epochal_2006 %A Koelle, Katia %A Cobey, Sarah %A Grenfell, Bryan %A Pascual, Mercedes %D 2006 %J Science %K corepape %P 1898-1903 %R 10.1126/science.1132745 %T Epochal Evolution Shapes the Phylodynamics of Interpandemic Influenza A (H3N2) in Humans %U http://www.sciencemag.org/cgi/content/abstract/314/5807/1898 %V 314 %X Human influenza A (subtype H3N2) is characterized genetically by the limited standing diversity of its hemagglutinin and antigenically by clusters that emerge and replace each other within 2 to 8 years. By introducing an epidemiological model that allows for differences between the genetic and antigenic properties of the virus's hemagglutinin, we show that these patterns can arise from cluster-specific immunity alone. Central to the formulation is a genotype-to-phenotype mapping, based on neutral networks, with antigenic phenotypes, not genotypes, determining the degree of strain cross-immunity. The model parsimoniously explains well-known, as well as previously unremarked, features of interpandemic influenza dynamics and evolution. It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions.

@article{koelle_epochal_2006, abstract = {Human influenza A (subtype H3N2) is characterized genetically by the limited standing diversity of its hemagglutinin and antigenically by clusters that emerge and replace each other within 2 to 8 years. By introducing an epidemiological model that allows for differences between the genetic and antigenic properties of the virus's hemagglutinin, we show that these patterns can arise from cluster-specific immunity alone. Central to the formulation is a genotype-to-phenotype mapping, based on neutral networks, with antigenic phenotypes, not genotypes, determining the degree of strain cross-immunity. The model parsimoniously explains well-known, as well as previously unremarked, features of interpandemic influenza dynamics and evolution. It captures the observed boom-and-bust pattern of viral evolution, with periods of antigenic stasis during which genetic diversity grows, and with episodic contraction of this diversity during cluster transitions. }, added-at = {2009-05-15T07:48:18.000+0200}, author = {Koelle, Katia and Cobey, Sarah and Grenfell, Bryan and Pascual, Mercedes}, biburl = {https://www.bibsonomy.org/bibtex/2f083540258bb84010e6990b6f4e3830c/ebo}, doi = {10.1126/science.1132745}, interhash = {c90bbbb8adc2848d9d8ae305a85c6957}, intrahash = {f083540258bb84010e6990b6f4e3830c}, journal = {Science}, journalkeywords = {BIO306,read,UBM\_report}, keywords = {corepape}, month = {#dec#}, pages = {1898-1903}, timestamp = {2009-05-15T07:48:18.000+0200}, title = {Epochal Evolution Shapes the Phylodynamics of Interpandemic Influenza A (H3N2) in Humans}, url = {http://www.sciencemag.org/cgi/content/abstract/314/5807/1898}, volume = 314, year = 2006 }