%0 Journal Article %1 Kraemer2011 %A Kraemer, Helena Chmura %D 2011 %J The Journal of clinical psychiatry %K ComparativeEffectivenessResearch ComparativeEffectivenessResearch:standards Humans Psychiatry Psychiatry:methods RandomizedControlledTrialsasTopic:standards ResearchDesign ResearchDesign:standards RCT %N 10 %P 1350-2 %R 10.4088/JCP.10com06607whi %T Another point of view: superiority, noninferiority, and the role of active comparators. %U http://www.ncbi.nlm.nih.gov/pubmed/22075101 %V 72 %X Despite substantial agreement with points made by Andrew C. Leon, PhD, in his article, I am not in complete agreement in a few areas. The definition of noninferiority proposed by Leon allows drugs somewhat less effective than placebo to be characterized as noninferior to placebo, and 2 active drugs may each be simultaneously noninferior to the other. Moreover, including a placebo arm in comparing 2 active drugs is of no use in deciding whether the study is well designed or not, since a significant difference between one of the active arms and the placebo may be due to chance or to a bias in the design. An alternative view of the situation is presented. %@ 1555-2101; 0160-6689

@article{Kraemer2011, abstract = {Despite substantial agreement with points made by Andrew C. Leon, PhD, in his article, I am not in complete agreement in a few areas. The definition of noninferiority proposed by Leon allows drugs somewhat less effective than placebo to be characterized as noninferior to placebo, and 2 active drugs may each be simultaneously noninferior to the other. Moreover, including a placebo arm in comparing 2 active drugs is of no use in deciding whether the study is well designed or not, since a significant difference between one of the active arms and the placebo may be due to chance or to a bias in the design. An alternative view of the situation is presented.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Kraemer, Helena Chmura}, biburl = {https://www.bibsonomy.org/bibtex/29bca600d01bf8d85b2b2120bb941aec1/jepcastel}, doi = {10.4088/JCP.10com06607whi}, interhash = {cb2d0277052d72a16381fa3d6828833e}, intrahash = {9bca600d01bf8d85b2b2120bb941aec1}, isbn = {1555-2101; 0160-6689}, issn = {1555-2101}, journal = {The Journal of clinical psychiatry}, keywords = {ComparativeEffectivenessResearch ComparativeEffectivenessResearch:standards Humans Psychiatry Psychiatry:methods RandomizedControlledTrialsasTopic:standards ResearchDesign ResearchDesign:standards RCT}, month = {10}, note = {7070<m:linebreak></m:linebreak>LR: 20120815; CI: (c) Copyright 2011; JID: 7801243; CON: J Clin Psychiatry. 2011 Oct;72(10):1344-9. PMID: 21367350; 2010/09/30 [received]; 2010/09/30 [accepted]; ppublish;}, number = 10, pages = {1350-2}, pmid = {22075101}, timestamp = {2023-05-04T08:59:38.000+0200}, title = {Another point of view: superiority, noninferiority, and the role of active comparators.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22075101}, volume = 72, year = 2011 }