%0 Journal Article %1 pmid9007998 %A Schultz, J. %A Ponting, C. P. %A Hofmann, K. %A Bork, P. %D 1997 %J Protein Sci. %K imported %P 249--253 %T SAM as a protein interaction domain involved in developmental regulation %V 6 %X More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.

@article{pmid9007998, abstract = {More than 60 previously undetected SAM domain-containing proteins have been identified using profile searching methods. Among these are over 40 EPH-related receptor tyrosine kinases (RPTK), Drosophila bicaudal-C, a p53 from Loligo forbesi, and diacyglycerol-kinase isoform delta. This extended dataset suggests that SAM is an evolutionary conserved protein binding domain that is involved in the regulation of numerous developmental processes among diverse eukaryotes. A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine.}, added-at = {2011-07-21T16:10:59.000+0200}, author = {Schultz, J. and Ponting, C. P. and Hofmann, K. and Bork, P.}, biburl = {https://www.bibsonomy.org/bibtex/271c7bf110b2a6c3b3b653f4623524a95/jschultz}, interhash = {cc1ec47015681aca86fa90066ff00be4}, intrahash = {71c7bf110b2a6c3b3b653f4623524a95}, journal = {Protein Sci.}, keywords = {imported}, month = Jan, pages = {249--253}, timestamp = {2011-07-21T16:11:01.000+0200}, title = {{{S}{A}{M} as a protein interaction domain involved in developmental regulation}}, volume = 6, year = 1997 }