%0 Journal Article %1 Altenberg:1994EEGP %A Wagner, Gunter P. %A Altenberg, Lee %D 1996 %J Evolution %K algorithms, biology, genetic genotype-phenotype map modular theoretical %N 3 %P 967--976 %T Complex Adaptations and the Evolution of Evolvability %U http://dynamics.org/Altenberg/PAPERS/CAEE/ %V 50 %X The problem of complex adaptations is studied in two largely disconnected research traditions: evolutionary biology and evolutionary computer science. This paper summarizes the results from both areas and compares their implications. In evolutionary computer science it was found that the Darwinian process of mutation, recombination and selection is not universally effective in improving complex systems like computer programs or chip designs. For adaptation to occur, these systems must possess "evolvability", i.e. the ability of random variations to sometimes produce improvement. It was found that evolvability critically depends on the way genetic variation maps onto phenotypic variation, an issue known as the representation problem. The genotype-phenotype map determines the variability of characters, which is the propensity to vary. Variability needs to be distinguished from variation, which are the actually realized differences between individuals. The genotype-phenotype map is the common theme underlying such varied biological phenomena as genetic canalization, developmental constraints, biological versatility, developmental dissociability, morphological integration, and many more. For evolutionary biology the representation problem has important implications: how is it that extant species acquired a genotype-phenotype map which allows improvement by mutation and selection? Is the genotype-phenotype map able to change in evolution? What are the selective forces, if any, that shape the genotype-phenotype map? We propose that the genotype-phenotype map can evolve by two main routes: epistatic mutations, or the creation of new genes. A common result for organismic design is modularity. By modularity we mean a genotype-phenotype map in which there are few pleiotropic effects among characters serving different functions, with pleiotropic effects falling mainly among characters that are part of a single functional complex. Such a design is expected to improve evolvability by limiting the interference between the adaptation of different functions. Several population genetic models are reviewed that are intended to explain the evolutionary origin of a modular design. While our current knowledge is insufficient to assess the plausibility of these models, they form the beginning of a framework for understanding the evolution of the genotype-phenotype map. Copyright 1996 Gunter Wagner and Lee Altenberg

@article{Altenberg:1994EEGP, abstract = {The problem of complex adaptations is studied in two largely disconnected research traditions: evolutionary biology and evolutionary computer science. This paper summarizes the results from both areas and compares their implications. In evolutionary computer science it was found that the Darwinian process of mutation, recombination and selection is not universally effective in improving complex systems like computer programs or chip designs. For adaptation to occur, these systems must possess {"}evolvability{"}, i.e. the ability of random variations to sometimes produce improvement. It was found that evolvability critically depends on the way genetic variation maps onto phenotypic variation, an issue known as the representation problem. The genotype-phenotype map determines the variability of characters, which is the propensity to vary. Variability needs to be distinguished from variation, which are the actually realized differences between individuals. The genotype-phenotype map is the common theme underlying such varied biological phenomena as genetic canalization, developmental constraints, biological versatility, developmental dissociability, morphological integration, and many more. For evolutionary biology the representation problem has important implications: how is it that extant species acquired a genotype-phenotype map which allows improvement by mutation and selection? Is the genotype-phenotype map able to change in evolution? What are the selective forces, if any, that shape the genotype-phenotype map? We propose that the genotype-phenotype map can evolve by two main routes: epistatic mutations, or the creation of new genes. A common result for organismic design is modularity. By modularity we mean a genotype-phenotype map in which there are few pleiotropic effects among characters serving different functions, with pleiotropic effects falling mainly among characters that are part of a single functional complex. Such a design is expected to improve evolvability by limiting the interference between the adaptation of different functions. Several population genetic models are reviewed that are intended to explain the evolutionary origin of a modular design. While our current knowledge is insufficient to assess the plausibility of these models, they form the beginning of a framework for understanding the evolution of the genotype-phenotype map. Copyright 1996 Gunter Wagner and Lee Altenberg}, added-at = {2008-06-19T17:46:40.000+0200}, author = {Wagner, Gunter P. and Altenberg, Lee}, biburl = {https://www.bibsonomy.org/bibtex/23c7084ca9db20706c328999141597f53/brazovayeye}, interhash = {d231c55053ac4d3699dca3d888220192}, intrahash = {3c7084ca9db20706c328999141597f53}, journal = {Evolution}, keywords = {algorithms, biology, genetic genotype-phenotype map modular theoretical}, notes = {survey connecting real genetics with evolutionary computation}, number = 3, pages = {967--976}, size = {24 pages}, timestamp = {2008-06-19T17:53:44.000+0200}, title = {Complex Adaptations and the Evolution of Evolvability}, url = {http://dynamics.org/Altenberg/PAPERS/CAEE/}, volume = 50, year = 1996 }