%0 Journal Article %1 citeulike:477564 %A Giuliano, K. A. %A Taylor, D. L. %C Cellomics Inc., Pittsburgh, PA 15238, USA. %D 1998 %J Trends Biotechnol %K biosensor methodology %N 3 %P 135--140 %R 10.1016/S0167-7799(97)01166-9 %T Fluorescent-protein biosensors: new tools for drug discovery. %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9523461 %V 16 %X Recent improvements in target discovery and high-throughput screening have increased the pressure at key points along the drug-discovery pipeline. High-content screening was developed to ease the bottlenecks formed at the target-validation and lead-optimization points, and a new generation of reagents that report on specific molecular processes in living cells (fluorescent-protein biosensors) have been important in its development. Creative designs of fluorescent-protein biosensors have emerged and been used to measure the molecular dynamics of macromolecules, metabolites and ions. Recent applications of fluorescent-protein biosensors to biological problems have provided a foundation for their use in biotechnology.

@article{citeulike:477564, abstract = {Recent improvements in target discovery and high-throughput screening have increased the pressure at key points along the drug-discovery pipeline. High-content screening was developed to ease the bottlenecks formed at the target-validation and lead-optimization points, and a new generation of reagents that report on specific molecular processes in living cells (fluorescent-protein biosensors) have been important in its development. Creative designs of fluorescent-protein biosensors have emerged and been used to measure the molecular dynamics of macromolecules, metabolites and ions. Recent applications of fluorescent-protein biosensors to biological problems have provided a foundation for their use in biotechnology.}, added-at = {2006-07-07T01:10:50.000+0200}, address = {Cellomics Inc., Pittsburgh, PA 15238, USA.}, author = {Giuliano, K. A. and Taylor, D. L.}, biburl = {https://www.bibsonomy.org/bibtex/2081b02b688bd100c86230e0d47363a43/biblio24}, citeulike-article-id = {477564}, comment = {mailto:giuliano@biodx.com/requested/wrong address}, doi = {10.1016/S0167-7799(97)01166-9}, interhash = {d4c3866604988cef7b2d3401ab55ecbc}, intrahash = {081b02b688bd100c86230e0d47363a43}, issn = {0167-7799}, journal = {Trends Biotechnol}, keywords = {biosensor methodology}, month = {March}, number = 3, pages = {135--140}, priority = {2}, timestamp = {2006-07-07T01:10:50.000+0200}, title = {Fluorescent-protein biosensors: new tools for drug discovery.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve\&db=pubmed\&dopt=Abstract\&list_uids=9523461}, volume = 16, year = 1998 }