Article,

Microwave induced synthesis of 4-hydroxy-3-methyl-7, 8-dihydroquinoline-5(6H)-one using proline catalyst

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World Journal of Biology Pharmacy and Health Sciences, 17 (1): 114–116 (May 2024)
DOI: 10.30574/wjbphs.2024.17.1.0018

Abstract

In the present investigation synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione using microwave heating using proline catalyst. The synthesis of Hexa-Hydro-Quinolone derivatives, carried out by sequential in situ, Michael Addition, Cyclisation, and Aromatization. A new protocol for one step synthesis of 4-hydroxy-3-methyl-7,8-dihydroquinolin-5(6H)-one was successfully demonstrated from cyclohexane-1,3-dione with 98% yield.

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