Abstract
This white paper by eighty members of the Complex Trait
Consortium presents a community's view on the approaches and
statistical analyses that are needed for the identification of
genetic loci that determine quantitative traits. Quantitative trait
loci (QTLs) can be identified in several ways, but is there a
definitive test of whether a candidate locus actually corresponds
to a specific QTL? Much of the genetic variation that underlies
disease susceptibility and morphology is complex and is governed by
loci that have quantitative effects on the phenotype. Gene�gene and
gene�environment interactions are common and make these loci
difficult to analyse. Here, we present a community's view on the
steps that are necessary to identify genetic loci that govern
quantitative traits, along with a set of interpretive
guidelines. This community mostly represents interests in the
analyses of rodent quantitative trait loci (QTLs), although many of
the same principles apply to other species.
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