%0 Journal Article %1 abdelhafez2018hepatoprotective %A Abdelhafez, O. H. %A Fawzy, M. A. %A Fahim, J. R. %A Desoukey, S. Y. %A Krischke, M. %A Mueller, M. J. %A Abdelmohsen, U. R. %D 2018 %J PLoS One %K Administration, Oral myOwn uni_network %N 8 %P e0202362 %R 10.1371/journal.pone.0202362 %T Hepatoprotective potential of Malvaviscus arboreus against carbon tetrachloride-induced liver injury in rats %U https://www.ncbi.nlm.nih.gov/pubmed/30138328https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202362&type=printable %V 13 %X Malvaviscus arboreus Cav. is a medicinal plant belonging to family Malvaceae with both ethnomedical and culinary value; however, its phytochemical and biological profiles have been scarcely studied. Accordingly, this work was designed to explore the chemical composition and the hepatoprotective potential of M. arboreus against carbon tetrachloride (CCl4)-induced hepatotoxicity. The total extract of the aerial parts and its derived fractions (petroleum ether, dichloromethane, ethyl acetate, and aqueous) were orally administered to rats for six consecutive days, followed by injection of CCl4 (1:1 v/v, in olive oil, 1.5 ml/kg, i.p.) on the next day. Results showed that the ethyl acetate and dichloromethane fractions significantly alleviated liver injury in rats as indicated by the reduced levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TB), and malondialdehyde (MDA), along with enhancement of the total antioxidant capacities of their livers, with the maximum effects were recorded by the ethyl acetate fraction. Moreover, the protective actions of both fractions were comparable to those of silymarin (100 mg/kg), and have been also substantiated by histopathological evaluations. On the other hand, liquid chromatography-high resolution electrospray ionization mass spectrometry (LC‒HR‒ESI‒MS) metabolomic profiling of the crude extract of M. arboreus aerial parts showed the presence of a variety of phytochemicals, mostly phenolics, whereas the detailed chemical analysis of the most active fraction (i.e. ethyl acetate) resulted in the isolation and identification of six compounds for the first time in the genus, comprising four phenolic acids; beta-resorcylic, caffeic, protocatechuic, and 4-hydroxyphenylacetic acids, in addition to two flavonoids; trifolin and astragalin. Such phenolic principles, together with their probable synergistic antioxidant and liver-protecting properties, seem to contribute to the observed hepatoprotective potential of M. arboreus.

@article{abdelhafez2018hepatoprotective, abstract = {Malvaviscus arboreus Cav. is a medicinal plant belonging to family Malvaceae with both ethnomedical and culinary value; however, its phytochemical and biological profiles have been scarcely studied. Accordingly, this work was designed to explore the chemical composition and the hepatoprotective potential of M. arboreus against carbon tetrachloride (CCl4)-induced hepatotoxicity. The total extract of the aerial parts and its derived fractions (petroleum ether, dichloromethane, ethyl acetate, and aqueous) were orally administered to rats for six consecutive days, followed by injection of CCl4 (1:1 v/v, in olive oil, 1.5 ml/kg, i.p.) on the next day. Results showed that the ethyl acetate and dichloromethane fractions significantly alleviated liver injury in rats as indicated by the reduced levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TB), and malondialdehyde (MDA), along with enhancement of the total antioxidant capacities of their livers, with the maximum effects were recorded by the ethyl acetate fraction. Moreover, the protective actions of both fractions were comparable to those of silymarin (100 mg/kg), and have been also substantiated by histopathological evaluations. On the other hand, liquid chromatography-high resolution electrospray ionization mass spectrometry (LC‒HR‒ESI‒MS) metabolomic profiling of the crude extract of M. arboreus aerial parts showed the presence of a variety of phytochemicals, mostly phenolics, whereas the detailed chemical analysis of the most active fraction (i.e. ethyl acetate) resulted in the isolation and identification of six compounds for the first time in the genus, comprising four phenolic acids; beta-resorcylic, caffeic, protocatechuic, and 4-hydroxyphenylacetic acids, in addition to two flavonoids; trifolin and astragalin. Such phenolic principles, together with their probable synergistic antioxidant and liver-protecting properties, seem to contribute to the observed hepatoprotective potential of M. arboreus.}, added-at = {2024-02-15T15:08:22.000+0100}, author = {Abdelhafez, O. H. and Fawzy, M. A. and Fahim, J. R. and Desoukey, S. Y. and Krischke, M. and Mueller, M. J. and Abdelmohsen, U. R.}, biburl = {https://www.bibsonomy.org/bibtex/20f3e4d8d3c2ef61b7134a06641807774/jvsi_all}, doi = {10.1371/journal.pone.0202362}, interhash = {db5426a9cc9109b4c076a8cbaec06c7b}, intrahash = {0f3e4d8d3c2ef61b7134a06641807774}, issn = {1932-6203 (Electronic) 1932-6203 (Linking)}, journal = {PLoS One}, keywords = {Administration, Oral myOwn uni_network}, note = {Abdelhafez, Omnia Hesham Fawzy, Michael Atef Fahim, John Refaat Desoukey, Samar Yehia Krischke, Markus Mueller, Martin J Abdelmohsen, Usama Ramadan eng Research Support, Non-U.S. Gov't 2018/08/24 PLoS One. 2018 Aug 23;13(8):e0202362. doi: 10.1371/journal.pone.0202362. eCollection 2018.}, number = 8, pages = {e0202362}, timestamp = {2024-02-15T15:11:55.000+0100}, title = {Hepatoprotective potential of Malvaviscus arboreus against carbon tetrachloride-induced liver injury in rats}, type = {Journal Article}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30138328https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0202362&type=printable}, volume = 13, year = 2018 }