%0 Journal Article %1 citeulike:7787405 %A Rijkers, G. %D 1998 %J Vaccine %K citeulikeExport immunology %N 14-15 %P 1396--1400 %R 10.1016/s0264-410x(98)00098-x %T Infant B cell responses to polysaccharide determinants %U http://dx.doi.org/10.1016/s0264-410x(98)00098-x %V 16 %X Newborns and infants up to the age of 1.5–2 years of age are unable to produce antibodies to bacterial capsular polysaccharides. As a consequence, children up to the age of 2 years have an increased susceptibility for infections with encapsulated bacteria. Capsular polysaccharides are classified as so-called T cell independent type 2 antigens and induce IgG2 antibodies. The mechanism of B lymphocyte activation by polysaccharides differs from that of protein antigens and involves co-stimulation by CD21 (type 2 complement receptor). Reduced expression of CD21 on neonatal B lymphocytes can explain unresponsiveness to polysaccharides. Polysaccharide protein conjugates have the ability to overcome unresponsiveness to polysaccharides early in life. The response induced is predominant IgG1.

@article{citeulike:7787405, abstract = {{Newborns and infants up to the age of 1.5–2 years of age are unable to produce antibodies to bacterial capsular polysaccharides. As a consequence, children up to the age of 2 years have an increased susceptibility for infections with encapsulated bacteria. Capsular polysaccharides are classified as so-called T cell independent type 2 antigens and induce IgG2 antibodies. The mechanism of B lymphocyte activation by polysaccharides differs from that of protein antigens and involves co-stimulation by CD21 (type 2 complement receptor). Reduced expression of CD21 on neonatal B lymphocytes can explain unresponsiveness to polysaccharides. Polysaccharide protein conjugates have the ability to overcome unresponsiveness to polysaccharides early in life. The response induced is predominant IgG1.}}, added-at = {2019-03-31T01:14:40.000+0100}, author = {Rijkers, G.}, biburl = {https://www.bibsonomy.org/bibtex/27bed80eef5ed9f1ff23a09d86300396c/dianella}, citeulike-article-id = {7787405}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/s0264-410x(98)00098-x}, doi = {10.1016/s0264-410x(98)00098-x}, interhash = {dbcffb9092ee37e95bc8af8e5ef48d57}, intrahash = {7bed80eef5ed9f1ff23a09d86300396c}, issn = {0264410X}, journal = {Vaccine}, keywords = {citeulikeExport immunology}, month = aug, number = {14-15}, pages = {1396--1400}, posted-at = {2010-09-05 02:45:23}, priority = {2}, timestamp = {2019-03-31T01:16:26.000+0100}, title = {{Infant B cell responses to polysaccharide determinants}}, url = {http://dx.doi.org/10.1016/s0264-410x(98)00098-x}, volume = 16, year = 1998 }