Article,

Thermodynamic System Drift in Protein Evolution

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PLOS Biology, 12 (11): 1-12 (November 2014)
DOI: 10.1371/journal.pbio.1001994

Abstract

Tracking the evolution of thermostability in resurrected ancestors of a heat-tolerant extremophile protein and its less heat tolerant Escherichia coli homologue shows how thermostability has probably explored different mechanisms of protein stabilization over evolutionary time.

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