%0 Journal Article %1 Deponte.2007 %A Deponte, Marcel %A Rahlfs, Stefan %A Becker, Katja %D 2007 %J Subcell Biochem %K Amino_Acid Animals Catalase Drug_Design Glutathione_Transferase Humans IFZ Peroxiredoxins Protozoa Protozoan_Infections Protozoan_Proteins Sequence_Homology Thioredoxins glutathione_peroxidase %P 219-229 %T Peroxiredoxin systems of protozoal parasites %V 44 %X Cellular redox metabolism is considered to be involved in the pathophysiology of diseases caused by protozoal parasites such as Toxoplasma, Trypanosoma, Leishmania, and Plasmodia. Redox reactions furthermore are thought to play a major role in the action of and the resistance to some clinically used antiparasitic drugs. Interestingly, in malarial parasites, the antioxidant enzymes catalase and glutathione peroxidase are absent which indicates a crucial role of the thioredoxin system in redox control. Besides a glutathione peroxidase-like thioredoxin peroxidase and a glutathione S-transferase with slight peroxidase activity, Plasmodium falciparum (the causative agent of tropical malaria) possesses four classical peroxiredoxins: Two peroxiredoxins of the typical 2-Cys Prx class, one 1-Cys peroxiredoxin with homology to the atypical 2-Cys Prx class, and a peroxiredoxin of the 1-Cys Prx class have been identified and partially characterized In our article we give an introduction to redox-b

@article{Deponte.2007, abstract = {Cellular redox metabolism is considered to be involved in the pathophysiology of diseases caused by protozoal parasites such as Toxoplasma, Trypanosoma, Leishmania, and Plasmodia. Redox reactions furthermore are thought to play a major role in the action of and the resistance to some clinically used antiparasitic drugs. Interestingly, in malarial parasites, the antioxidant enzymes catalase and glutathione peroxidase are absent which indicates a crucial role of the thioredoxin system in redox control. Besides a glutathione peroxidase-like thioredoxin peroxidase and a glutathione S-transferase with slight peroxidase activity, Plasmodium falciparum (the causative agent of tropical malaria) possesses four classical peroxiredoxins: Two peroxiredoxins of the typical 2-Cys Prx class, one 1-Cys peroxiredoxin with homology to the atypical 2-Cys Prx class, and a peroxiredoxin of the 1-Cys Prx class have been identified and partially characterized In our article we give an introduction to redox-b}, added-at = {2008-10-14T16:07:18.000+0200}, author = {Deponte, Marcel and Rahlfs, Stefan and Becker, Katja}, biburl = {https://www.bibsonomy.org/bibtex/2d7f6838237ede031ae7ed91b15cf2178/nutribiochem}, interhash = {e331e800abd8247e9849d59183dbb339}, intrahash = {d7f6838237ede031ae7ed91b15cf2178}, issn = {0306-0225}, journal = {Subcell Biochem}, keywords = {Amino_Acid Animals Catalase Drug_Design Glutathione_Transferase Humans IFZ Peroxiredoxins Protozoa Protozoan_Infections Protozoan_Proteins Sequence_Homology Thioredoxins glutathione_peroxidase}, pages = {219-229}, timestamp = {2008-10-14T16:08:42.000+0200}, title = {Peroxiredoxin systems of protozoal parasites}, volume = 44, year = 2007 }