Article,

Shaking up genome engineering

, and .
Nature Biotechnology, 28 (8): 812--813 (Aug 1, 2010)
DOI: 10.1038/nbt0810-812

Abstract

Systematic approaches to mutate and characterize the function of every gene in a microbe have been hampered by the need to manually create thousands of separate strains through tedious genetic manipulation. In this issue, Warner et al. describe an approach to create and characterize rationally modified versions of almost every gene in Escherichia coli.

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