%0 Journal Article %1 arroll2009avp %A B, Arroll %A CR, Elley %A T, Fishman %A FA, Goodyear-Smith %A T, Kenealy %A G, Blashki %A N, Kerse %A S, MacGillivray %D 2009 %J Cochrane Database of Systematic Reviews %K SSRI depression meta-analysis placebo psychology %T Antidepressants versus placebo for depression in primary care %U http://www.cochrane.org/reviews/en/ab007954.html %V 3 %X Depression in the primary care setting is very common. However, most systematic reviews of antidepressant treatment have included trials conducted in secondary care settings. There has been doubt about the effectiveness of antidepressants in primary care, and hence the impetus to do this review. Through extensive searches of the literature we found 14 studies conducted in adults (not the elderly) in primary care setting, in which tricyclic antidepressants (TCAs) or selective serotonin reupdate inhibitors (SSRIs) were compared against a placebo control group in the treatment of depression. The results showed that both TCAs and SSRIs were effective for depression. Most of the studies were supported by funds from pharmaceutical companies and were of short duration. There appeared to be more adverse effects with TCAs than with SSRIs, however rates of withdrawal from study medication due to adverse effects were very similar between the two antidepressant classes. Adverse effects not leading to medication cessation seemed to be more common with TCAs than SSRIs.

@article{arroll2009avp, abstract = {Depression in the primary care setting is very common. However, most systematic reviews of antidepressant treatment have included trials conducted in secondary care settings. There has been doubt about the effectiveness of antidepressants in primary care, and hence the impetus to do this review. Through extensive searches of the literature we found 14 studies conducted in adults (not the elderly) in primary care setting, in which tricyclic antidepressants (TCAs) or selective serotonin reupdate inhibitors (SSRIs) were compared against a placebo control group in the treatment of depression. The results showed that both TCAs and SSRIs were effective for depression. Most of the studies were supported by funds from pharmaceutical companies and were of short duration. There appeared to be more adverse effects with TCAs than with SSRIs, however rates of withdrawal from study medication due to adverse effects were very similar between the two antidepressant classes. Adverse effects not leading to medication cessation seemed to be more common with TCAs than SSRIs.}, added-at = {2009-08-24T17:22:19.000+0200}, author = {B, Arroll and CR, Elley and T, Fishman and FA, Goodyear-Smith and T, Kenealy and G, Blashki and N, Kerse and S, MacGillivray}, biburl = {https://www.bibsonomy.org/bibtex/2dd681fe3c693f667a861ab88ae0c6b18/unhammer}, interhash = {e91663fe7114d5b519e4ce687b5a555d}, intrahash = {dd681fe3c693f667a861ab88ae0c6b18}, journal = {Cochrane Database of Systematic Reviews}, keywords = {SSRI depression meta-analysis placebo psychology}, note = {Art. No.: CD 007954. DOI: 10. 1002 / 14651858. CD 007954}, timestamp = {2009-08-24T17:22:19.000+0200}, title = {Antidepressants versus placebo for depression in primary care}, url = {http://www.cochrane.org/reviews/en/ab007954.html}, volume = 3, year = 2009 }