%0 Journal Article %1 Frank.2008 %A Frank, Bernd %A Burwinkel, Barbara %A Bermejo, Justo Lorenzo %A Försti, Asta %A Hemminki, Kari %A Houlston, Richard %A Mangold, Elisabeth %A Rahner, Nils %A Friedl, Waltraut %A Friedrichs, Nicolaus %A Buettner, Reinhard %A Engel, Christoph %A Loeffler, Markus %A Holinski-Feder, Elke %A Morak, Monika %A Keller, Gisela %A Schackert, Hans K. %A Krüger, Stefan %A Goecke, Timm %A Moeslein, Gabriela %A Kloor, Matthias %A Gebert, Johannes %A Kunstmann, Erdmute %A Schulmann, Karsten %A Rüschoff, Josef %A Propping, Peter %D 2008 %J Cancer letters %K Adolescent Adult Aged Aged,_80_and_over Case-Control_Studies Child Colorectal_Neoplasms/genetics Female Genetic_Predisposition_to_Disease Germany Humans Male Middle_Aged Polymorphism,_Single_Nucleotide Reproducibility_of_Results %N 1 %P 153–157 %T Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families %V 271 %X Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.

@article{Frank.2008, abstract = {Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.}, added-at = {2014-10-15T15:03:47.000+0200}, author = {Frank, Bernd and Burwinkel, Barbara and Bermejo, Justo Lorenzo and Försti, Asta and Hemminki, Kari and Houlston, Richard and Mangold, Elisabeth and Rahner, Nils and Friedl, Waltraut and Friedrichs, Nicolaus and Buettner, Reinhard and Engel, Christoph and Loeffler, Markus and Holinski-Feder, Elke and Morak, Monika and Keller, Gisela and Schackert, Hans K. and Krüger, Stefan and Goecke, Timm and Moeslein, Gabriela and Kloor, Matthias and Gebert, Johannes and Kunstmann, Erdmute and Schulmann, Karsten and Rüschoff, Josef and Propping, Peter}, biburl = {https://www.bibsonomy.org/bibtex/24dad9c275cb34a81b1a69cbb1e7bb1e9/drtester}, interhash = {ed4af4414f29c020beb77598f2ef7141}, intrahash = {4dad9c275cb34a81b1a69cbb1e7bb1e9}, journal = {Cancer letters}, keywords = {Adolescent Adult Aged Aged,_80_and_over Case-Control_Studies Child Colorectal_Neoplasms/genetics Female Genetic_Predisposition_to_Disease Germany Humans Male Middle_Aged Polymorphism,_Single_Nucleotide Reproducibility_of_Results}, number = 1, pages = {153–157}, timestamp = {2014-10-15T15:03:47.000+0200}, title = {Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families}, volume = 271, year = 2008 }