%0 Journal Article %1 Guat_2002_941 %A Guatimosim, Silvia %A Dilly, Keith %A Santana, L. Fernando %A Jafri, M. Saleet %A Sobie, Eric A %A Lederer, W. J. %D 2002 %J J. Mol. Cell. Cardiol. %K Animals; Calci; Calcium Calcium; Cardiac; Channel; Channels, Congestive; Failure, Guinea Heart L-Type Myocardium; Myocytes, Pigs; Rats; Receptor Release Ryanodine Signaling; um %N 8 %P 941--950 %R doi:10.1006/jmcc.2002.2032 %T Local Ca$^2+$ signaling and EC coupling in heart: Ca$^2+$ sparks and the regulation of the Ca$^2+$(i) transient. %U http://dx.doi.org/10.1006/jmcc.2002.2032 %V 34 %X The elementary event of Ca$^2+$ release in heart is the Ca$^2+$ spark. It occurs at a low rate during diastole, activated only by the low cytosolic Ca$^2+$(i). Synchronized activation of many sparks is due to the high local Ca$^2+$(i) in the region surrounding the sarcoplasmic reticulum (SR) Ca$^2+$ release channels and is responsible for the systolic Ca$^2+$(i) transient. The biophysical basis of this calcium signaling is discussed. Attention is placed on the local organization of the ryanodine receptors (SR Ca$^2+$ release channels, RyRs) and the other proteins that underlie and modulate excitation-contraction (EC) coupling. A brief review of specific elements that regulate SR Ca$^2+$ release (including SR lumenal Ca$^2+$ and coupled gating of RyRs) is presented. Finally integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.

@article{Guat_2002_941, abstract = {The elementary event of {C}a$^{2+}$ release in heart is the {C}a$^{2+}$ spark. It occurs at a low rate during diastole, activated only by the low cytosolic [{C}a$^{2+}$](i). Synchronized activation of many sparks is due to the high local [{C}a$^{2+}$](i) in the region surrounding the sarcoplasmic reticulum (SR) {C}a$^{2+}$ release channels and is responsible for the systolic [{C}a$^{2+}$](i) transient. The biophysical basis of this calcium signaling is discussed. Attention is placed on the local organization of the ryanodine receptors (SR {C}a$^{2+}$ release channels, RyRs) and the other proteins that underlie and modulate excitation-contraction (EC) coupling. A brief review of specific elements that regulate SR {C}a$^{2+}$ release (including SR lumenal {C}a$^{2+}$ and coupled gating of RyRs) is presented. Finally integrative calcium signaling in heart is presented in the context of normal heart function and heart failure.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Guatimosim, Silvia and Dilly, Keith and Santana, L. Fernando and Jafri, M. Saleet and Sobie, Eric A and Lederer, W. J.}, biburl = {https://www.bibsonomy.org/bibtex/22276510192899a14857dd15bf88be436/hake}, description = {The whole bibliography file I use.}, doi = {doi:10.1006/jmcc.2002.2032}, file = {Guat_2002_941.pdf:Guat_2002_941.pdf:PDF}, interhash = {ee22b156a2132f82ae40c1c46168ba67}, intrahash = {2276510192899a14857dd15bf88be436}, journal = {J. Mol. Cell. Cardiol.}, keywords = {Animals; Calci; Calcium Calcium; Cardiac; Channel; Channels, Congestive; Failure, Guinea Heart L-Type Myocardium; Myocytes, Pigs; Rats; Receptor Release Ryanodine Signaling; um}, month = Aug, number = 8, pages = {941--950}, pii = {S0022282802920328}, pmid = {12234764}, timestamp = {2009-06-03T11:21:13.000+0200}, title = {Local {C}a$^{2+}$ signaling and EC coupling in heart: {C}a$^{2+}$ sparks and the regulation of the [{C}a$^{2+}$](i) transient.}, url = {http://dx.doi.org/10.1006/jmcc.2002.2032}, volume = 34, year = 2002 }