%0 Journal Article %1 jppres2020preparation %A Febriyenti, Febriyenti %A Indra, Peki %A Zaini, Erizal %A Ismed, Friardi %A Lucida, Henny %D 2020 %E JPPRes, %J Journal of Pharmacy & Pharmacognosy Research %K dissolution-profile polyvinylpyrrolidone quercetin solid-dispersion solubility %N 2 %P 127-134 %T Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion %U http://jppres.com/jppres/pdf/vol8/jppres19.729_8.2.127.pdf %V 8 %X Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of quercetin. Aims: To prepare and characterize quercetin solid dispersion using polyvinylpyrrolidone (PVP) K-30. Methods: Solid dispersions (SDs) were prepared by spray drying technique at quercetin/PVP K-30 ratios of 10/90, 20/80, 30/70, 40/60 and 50/50. A physical mixture of quercetin/PVP K-30 (50/50) and pure quercetin were used as comparisons. The SDs were characterized by powder X-Ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform IR (FTIR) spectroscopy, solubility and dissolution studies. The effect of the drug/polymer ratio on the solubility of quercetin was also studied. Results: Quercetin SDs appeared as amorphous form as confirmed by XRD. Quercetin was better dispersed as the drug/polymer ratio decreased. SD with ratio 10/90 showed regular spherical particles in the size range of 0-35 µm. The solubility of quercetin increased with decreasing drug/polymer ratio. Preparation of SDs influence the solubility significantly (p<0.01). The increase in solubility is probably due to a hydrogen bond between quercetin and PVP K30 as confirmed by FTIR spectra. SD with ratio 10/90 showed a high dissolution rate (95.12 ± 1.83%) within 120 min in comparison to pure quercetin (19.37 ± 0.58%) or physical mixture (37.85 ± 0.85%). Conclusions: Preparation of quercetin SDs with PVP K30 by spray drying technique results in amorphous spherical particles. There was an increase in solubility and percent dissolved with a decrease in drug/polymer ratio.

@article{jppres2020preparation, abstract = {Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of quercetin. Aims: To prepare and characterize quercetin solid dispersion using polyvinylpyrrolidone (PVP) K-30. Methods: Solid dispersions (SDs) were prepared by spray drying technique at quercetin/PVP K-30 ratios of 10/90, 20/80, 30/70, 40/60 and 50/50. A physical mixture of quercetin/PVP K-30 (50/50) and pure quercetin were used as comparisons. The SDs were characterized by powder X-Ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform IR (FTIR) spectroscopy, solubility and dissolution studies. The effect of the drug/polymer ratio on the solubility of quercetin was also studied. Results: Quercetin SDs appeared as amorphous form as confirmed by XRD. Quercetin was better dispersed as the drug/polymer ratio decreased. SD with ratio 10/90 showed regular spherical particles in the size range of 0-35 µm. The solubility of quercetin increased with decreasing drug/polymer ratio. Preparation of SDs influence the solubility significantly (p<0.01). The increase in solubility is probably due to a hydrogen bond between quercetin and PVP K30 as confirmed by FTIR spectra. SD with ratio 10/90 showed a high dissolution rate (95.12 ± 1.83%) within 120 min in comparison to pure quercetin (19.37 ± 0.58%) or physical mixture (37.85 ± 0.85%). Conclusions: Preparation of quercetin SDs with PVP K30 by spray drying technique results in amorphous spherical particles. There was an increase in solubility and percent dissolved with a decrease in drug/polymer ratio.}, added-at = {2020-01-19T06:11:14.000+0100}, author = {Febriyenti, Febriyenti and Indra, Peki and Zaini, Erizal and Ismed, Friardi and Lucida, Henny}, biburl = {https://www.bibsonomy.org/bibtex/2602b724fd179ec04b1c2f07aad6c36a4/jppres}, editor = {JPPRes}, interhash = {ef2e69edbe82e08d41e895c8a138ca42}, intrahash = {602b724fd179ec04b1c2f07aad6c36a4}, issn = {0719-4250}, journal = {Journal of Pharmacy & Pharmacognosy Research}, keywords = {dissolution-profile polyvinylpyrrolidone quercetin solid-dispersion solubility}, language = {Eng}, month = {Mar-Apr}, number = 2, pages = {127-134}, timestamp = {2020-01-19T06:40:48.000+0100}, title = {Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion}, url = {http://jppres.com/jppres/pdf/vol8/jppres19.729_8.2.127.pdf}, volume = 8, year = 2020 }