%0 Journal Article %1 tian2008analysis %A Tian, Chao %A Plenge, Robert M %A Ransom, Michael %A Lee, Annette %A Villoslada, Pablo %A Selmi, Carlo %A Klareskog, Lars %A Pulver, Ann E %A Qi, Lihong %A Gregersen, Peter K %A Seldin, Michael F %D 2008 %I Public Library of Science %J PLoS Genet %K PCA inversions spatial_structure %N 1 %P e4 %R 10.1371/journal.pgen.0040004 %T Analysis and Application of European Genetic Substructure Using 300K SNP Information %U http://dx.plos.org/10.1371%2Fjournal.pgen.0040004 %V 4 %X Ancestry differences corresponding to ethnic groups may be important in determining disease risk factors and optimizing treatment. Our study further defines ancestry relationship among different European ethnic groups by examining over 300 thousand variations in DNA, in over 2,000 individuals. This study allowed a clearer ascertainment of differences that could not be discerned in smaller studies using more limited numbers of DNA variations. We show clear differences among European American participants of different self-identified ethnic affiliation. The analyses showed multiple components of variation. The components showing the largest variations generally corresponded to the grandparental country or region of origin within Europe. We also show the importance of applying this information in determining genetic risk factors for complex diseases. Moreover, the results have enabled a better selection of smaller numbers of DNA variations that can be used in future disease studies to identify more homogenous participant groups and minimize false positive and false negative results in assessing genetic risk factors for disease.

@article{tian2008analysis, abstract = {Ancestry differences corresponding to ethnic groups may be important in determining disease risk factors and optimizing treatment. Our study further defines ancestry relationship among different European ethnic groups by examining over 300 thousand variations in DNA, in over 2,000 individuals. This study allowed a clearer ascertainment of differences that could not be discerned in smaller studies using more limited numbers of DNA variations. We show clear differences among European American participants of different self-identified ethnic affiliation. The analyses showed multiple components of variation. The components showing the largest variations generally corresponded to the grandparental country or region of origin within Europe. We also show the importance of applying this information in determining genetic risk factors for complex diseases. Moreover, the results have enabled a better selection of smaller numbers of DNA variations that can be used in future disease studies to identify more homogenous participant groups and minimize false positive and false negative results in assessing genetic risk factors for disease.}, added-at = {2014-08-15T20:16:51.000+0200}, author = {Tian, Chao and Plenge, Robert M and Ransom, Michael and Lee, Annette and Villoslada, Pablo and Selmi, Carlo and Klareskog, Lars and Pulver, Ann E and Qi, Lihong and Gregersen, Peter K and Seldin, Michael F}, biburl = {https://www.bibsonomy.org/bibtex/2406567feebf0bdf81c5cf7e4b2e54481/peter.ralph}, doi = {10.1371/journal.pgen.0040004}, interhash = {f14cd06f4636ab7c047648b0d638693f}, intrahash = {406567feebf0bdf81c5cf7e4b2e54481}, journal = {PLoS Genet}, keywords = {PCA inversions spatial_structure}, month = {01}, number = 1, pages = {e4}, publisher = {Public Library of Science}, timestamp = {2014-08-15T20:16:51.000+0200}, title = {Analysis and Application of European Genetic Substructure Using 300{K} {SNP} Information}, url = {http://dx.plos.org/10.1371%2Fjournal.pgen.0040004}, volume = 4, year = 2008 }