%0 Book Section %1 statphys23_0472 %A Cerreti, F. %A Servedio, V.D.P. %A Buttŕ, P. %A Triolo, L. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K biological chemotaxis networks statphys23 topic-10 %T Two dimensional explicit molecular dynamics simulation of endothelial cells under the effect of chemotaxis %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=472 %X Endothelial cells are responsible for the formation of the capillary blood vessel network. By means of explicit molecular dynamics simulations, we analyze a system of endothelial cells whose motion is governed by the gradient of the concentration of a chemical substance, which the cells themselves produce (chemotaxis). The characteristic time of degradation of the substance introduces a characteristic length in the system. We show that cells organize into filaments with characteristic lengths, before collapsing all together. We refine our simulation by introducing a hard core repulsive force between cells and a force mimicking the peculiarity of endothelial cells to preserve the direction of their motion (persistence). We find an agreement with the experiments, as well as with continuum calculations based on the solution of fluid dynamics equations and present in the literature. With respect to the latter methods, our method is more intuitive and easier to implement.

@incollection{statphys23_0472, abstract = {Endothelial cells are responsible for the formation of the capillary blood vessel network. By means of explicit molecular dynamics simulations, we analyze a system of endothelial cells whose motion is governed by the gradient of the concentration of a chemical substance, which the cells themselves produce (chemotaxis). The characteristic time of degradation of the substance introduces a characteristic length in the system. We show that cells organize into filaments with characteristic lengths, before collapsing all together. We refine our simulation by introducing a hard core repulsive force between cells and a force mimicking the peculiarity of endothelial cells to preserve the direction of their motion (persistence). We find an agreement with the experiments, as well as with continuum calculations based on the solution of fluid dynamics equations and present in the literature. With respect to the latter methods, our method is more intuitive and easier to implement.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Cerreti, F. and Servedio, V.D.P. and Buttŕ, P. and Triolo, L.}, biburl = {https://www.bibsonomy.org/bibtex/280205eea6877d2dfad263e2baeef1e94/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {f50a558fbd4b65133945b98d5baaf903}, intrahash = {80205eea6877d2dfad263e2baeef1e94}, keywords = {biological chemotaxis networks statphys23 topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:21.000+0200}, title = {Two dimensional explicit molecular dynamics simulation of endothelial cells under the effect of chemotaxis}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=472}, year = 2007 }