Article,

A literature network of human genes for high-throughput analysis of gene expression

, , , and .
Nature Genetics, 28 (1): 21-28 (May 2001)

Abstract

From the website: Why PubGene? PubGene is designed to present information on genes, proteins and related keywords in an organized and intuitive form. Although researchers enjoy a wealth of easy access information from public databases it is a challenge to retrieve information efficiently in the context of individual genes. There are more than twelve million MEDLINE records in the electronically searchable PubMed data base at the National Library of Medicine. About ten-thousand new records are added every week. Searches are confounded by the fact that many genes are known by several synonyms, as well as certain synonyms being ambiguously mapped to several genes. To further complicate matters, gene naming across species is not consistent; for example, genes studied in C. elegans may not be easily recognized by identifiers of their human equivalents. PubGene navigates these many obstacles to provide researcher with up-to-date and comprehensive information on individual genes, their associated proteins and their relationships to other genes. (For a discussion of the issue, see, for example Nature 2001: 411:631-2, PMID: 11395736). Exhaustive and up to date information PubGene subscribers use a graphic interface to access databases that catalogue the occurrence of symbols and phrases identifying genes in the scientific literature. Databases are updated on a biweekly basis through searches of MEDLINE records. Searches are performed using a list of synonyms for each gene that include the primary gene ID (as listed in Entrez Gene) and other symbols and phrases used to identify the gene and its protein product. Furthermore, the graphic interface can present lists of articles, allowing the researcher to find all records mentioning the gene. Discover relationships between genes PubGene not only catalogues individual genes but gene pairs. That is, PubGene lists records that co-cite gene identifiers. Co-citation suggests biological relationship between the implicated genes (Nature Genetics 2001 28:21-8, PMID 11326270). PubGene uses co-citation to create networks of gene identifiers, allowing the possibility for the discovery of relationships between two genes via an intermediary gene. In addition to lists of articles, PubGene can search for keywords using gene identifiers, or use keywords to find genes (MeSH, GO and chemical identifiers). Multiple gene identifiers can be submitted at a time to check for relationships between these.

Tags

Users

  • @huiyangsfsu

Comments and Reviews