PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.
Want to write shorter, cleaner code? Have an unfortunate situation where you need to fit as much as you can in one expression? Prefer a quick dose of hacks to spending the rest of your life reading the docs? You've come to the right place.