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Dissolution is an important preceding step for the absorption of drugs in class II of the Biopharmaceutics Classification System (BCS) resulting in poor bioavailability. This current study was directed at determining the outcome of in situ micronization technique on the dissolution and solubility profiles of paracetamol. Six formulations of paracetamol microcrystals were produced by the solvent change method using HPMC and PVP K30 as stabilizing agents. The solubility, percentage drug content, and dissolution patterns of the produced microcrystals were all tested. The study disclosed that paracetamol solubility was increased up to 5-fold in the PVP K30 stabilized paracetamol microcrystal and a 4.5-fold increase for HPMC stabilized paracetamol microcrystal. The time course of dissolution was improved significantly from 0.6%/min for plain paracetamol to 1.1%/min and 1.2%/min for HPMC and PVP K30 stabilized paracetamol microcrystal respectively. Formulation P6, with 0.08 g of PVP K30 as stabilizing agents and an anti-solvent to solvent ratio of 1:6 was the optimized formulation having a 5-fold solubility increase, 98.3% content of active and 95.32% drug release in 60 minutes. The solvent change strategy of the in situ micronization technique could be used for the augmentation of solubility and dissolution of paracetamol.
Top position in search results not only depends on how popular content you have but also how your website is designed.
This means that SEO and website design have an internal relation during website creation. Let’s have some points and a
brief explanation of how these two fields are interrelated.
In a broader mathematical or computational perspective, an optimization problem is defined as a problem of finding the best solution from all feasible solutions. In terms of Machine Learning and…
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S. Bin, S. Volke, G. Scheuermann, and M. Middendorf. Theory and Practice of Natural Computing, volume 8890 of Lecture Notes in Computer Science, Springer International Publishing, (2014)
E. Pankratov. Mechatronics and Applications: An International Journal (MECHATROJ), 2 (1):
123-135(March 2024)cite arxiv:1108.2888Comment: A&A letters, in press.
D. Schlör, J. Pfister, and A. Hotho. 2023 the 7th International Conference on Medical and Health Informatics (ICMHI), page 136–141. New York, NY, USA, Association for Computing Machinery, (2023)
R. Pryzant, D. Iter, J. Li, Y. Lee, C. Zhu, and M. Zeng. Proceedings of the 2023 Conference on Empirical Methods in Natural Language Processing, page 7957--7968. Singapore, Association for Computational Linguistics, (December 2023)