qooxdoo is a comprehensive and innovative framework for creating rich internet applications (RIAs). Leveraging object-oriented JavaScript allows developers to build impressive cross-browser applications. No HTML, CSS nor DOM knowledge is needed.
SmartGWT is a GWT based framework that allows you to not only utilize its comprehensive widget library for your application UI, but also tie these widgets in with your server-side for data management. SmartGWT is based on the powerful and mature SmartClient library.