This tutorial shows you how to feed data directly from a Google Spreadsheet rather than from a file. The advantage of this is that you can edit your data in Google Spreadsheets' user interface. Here is an example.
PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.