Zimbra is open source server and client software for messaging and collaboration - email, group calendaring, contacts, and web document management and authoring. The Zimbra server is available for Linux, Mac OS X, appliances, and virtualization platforms. The Zimbra Web 2.0 Ajax client runs on Firefox, Safari, and IE, and features easy integration / mash-ups of web portals, business applications, and VoIP using web services.
RoundCube Webmail is a browser-based multilingual IMAP client with an application-like user interface. It provides full functionality you expect from an e-mail client, including MIME support, address book, folder manipulation, message searching and spell checking. RoundCube Webmail is written in PHP and requires a MySQL or Postgres database. The user interface is fully skinnable using XHTML and CSS 2.