Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
Dr. Noboru Ashida, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaramachi, Shogoin Sakyo-ku, Kyoto 606-8507, Japan. Voice +81-75-751-3465; fax: +81-75-751-3574; ash@kuhp.kyoto.u.ac.jp.
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY. Judith Branger, Bernt van den Blink, Sebastiaan Weijer, Abhya Gupta, Sander J.H. van Deventer, C. Erik Hack, Maikel P. Peppelenbosch, and Tom van der Poll
The anti-inflammatory potential of an oral p38 MAPK inhibitor in humans in vivo suggests that p38 MAPK inhibitors may provide a new therapeutic option in the treatment of inflammatory diseases. Boehringer Ingelheim. 2002 Branger J, et al
R. Winstel, S. Freund, C. Krasel, E. Hoppe, and M. Lohse. Proc Natl Acad Sci U S A, 93 (5):
2105-9(March 1996)Winstel, R Freund, S Krasel, C Hoppe, E Lohse, M J Research Support,
Non-U.S. Gov't United states Proceedings of the National Academy
of Sciences of the United States of America Proc Natl Acad Sci U
S A. 1996 Mar 5;93(5):2105-9..
J. Vilardaga, V. Nikolaev, K. Lorenz, S. Ferrandon, Z. Zhuang, and M. Lohse. Nat Chem Biol, 4 (2):
126-31(February 2008)Vilardaga, Jean-Pierre Nikolaev, Viacheslav O Lorenz, Kristina Ferrandon,
Sebastien Zhuang, Zhenjie Lohse, Martin J Research Support, Non-U.S.
Gov't United States Nature chemical biology Nat Chem Biol. 2008 Feb;4(2):126-31.
Epub 2008 Jan 13..
M. Trincavelli, D. Tuscano, M. Marroni, K. Klotz, A. Lucacchini, and C. Martini. Biochim Biophys Acta, 1591 (1-3):
55-62(August 2002)Trincavelli, M Letizia Tuscano, Daniela Marroni, Matteo Klotz, Karl-Norbert
Lucacchini, Antonio Martini, Claudia Research Support, Non-U.S. Gov't
Netherlands Biochimica et biophysica acta Biochim Biophys Acta. 2002
Aug 19;1591(1-3):55-62..
J. Slupsky, U. Quitterer, C. Weber, P. Gierschik, M. Lohse, and U. Rapp. Curr Biol, 9 (17):
971-4(September 1999)Slupsky, J R Quitterer, U Weber, C K Gierschik, P Lohse, M J Rapp,
U R Research Support, Non-U.S. Gov't England Current biology : CB
Curr Biol. 1999 Sep 9;9(17):971-4..
A. Ruiz-Gomez, J. Humrich, C. Murga, U. Quitterer, M. Lohse, and J. Mayor. J Biol Chem, 275 (38):
29724-30(September 2000)Ruiz-Gomez, A Humrich, J Murga, C Quitterer, U Lohse, M J Mayor,
F Jr Research Support, Non-U.S. Gov't United states The Journal of
biological chemistry J Biol Chem. 2000 Sep 22;275(38):29724-30..
S. Reiner, N. Ziegler, C. Leon, K. Lorenz, K. von Hayn, C. Gachet, M. Lohse, and C. Hoffmann. Mol Pharmacol, 76 (6):
1162-71(December 2009)Reiner, Susanne Ziegler, Nicole Leon, Catherine Lorenz, Kristina
von Hayn, Kathrin Gachet, Christian Lohse, Martin J Hoffmann, Carsten
Research Support, Non-U.S. Gov't United States Molecular pharmacology
Mol Pharmacol. 2009 Dec;76(6):1162-71. Epub 2009 Sep 9..