?. J. Virol., 81 (15):
8211-8224(2007)"HCV replicates as a quasispecies rather than as a clonal population. (...) The average amino acid difference between the consensus sequence and the individual quasispecies variants was 1.8%, which was smaller than the average distance between the quasispecies variants themselves (2.3%). Phylogenetic analyses revealed that the consensus sequence was either in the center or near the base of the phylogenetic tree for each HCV gene.".