Question  Is uncomplicated childhood-onset epilepsy associated with increased brain amyloid accumulation?

Findings  In this population-based case-control study of Finnish adults who had childhood epilepsy and were followed up prospectively for more than 50 years from their disease onset and a group of matched controls, individuals with childhood-onset epilepsy, and particularly APOE ε4 carriers, had an increased brain amyloid load as measured with positron emission tomography at late middle age.

Meaning  Childhood-onset epilepsy is linked with a biomarker that might be associated with accelerated brain aging and can be considered as a neurobiological predisposition to later-life cognitive disorders. Please contact the library to request a copy of this article - http://bit.ly/1Xyazai