Systemic lupus erythematosus (SLE) predominantly affects women. Clinical phenotype and outcomes in SLE may vary by sex and are further complicated by unique concerns that are dependent upon sex‐defined roles. We aimed to describe sex differences in disease‐specific quality of life (QoL) assessment scores using the Lupus Patient‐Reported Outcome (LupusPRO) tool in a large international study. To read the full article, log in using your NHS OpenAthens details.